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Antileishmanial and trypanocidal activity of Brazilian Cerrado plants.
Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigote of Trypanosoma cruzi, and among the selected plants, Casearia sylvestris var.
The larvicidal properties of these species are described for the first time, and may prove to be promising in active chemical compound isolation.
In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies.
Twenty-seven species of native Brazilian Cerrado plants commonly used by traditional healers to treat malaria and other diseases were collected and 204 hexanic and ethanolic extracts obtained by maceration and showed significant inhibition rates of Plasmodium falciparum growth.
Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied.
Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae.
The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated and a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol) was quite potent against A. aeEgypti larvae.
Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua.
Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6
Down-modulation of nitric oxide production in murine macrophages treated with crude plant extracts from the Brazilian Cerrado.
The ethanolic stem bark and leaf extracts of Serjania lethalis and Cupania vernalis, respectively, almost completely inhibited the production of NO by J774 macrophages, indicating potential sources of active compounds that might be used as anti-inflammatory agents.
Development of gel with Matricaria recutita L. extract for topic application and evaluation of physical-chemical stability and toxicity
SUMMARY. Matricaria recutita L. (Asteraceae), better known as chamomile, has been used due to its pharmacological properties. Laboratory-manufactured gels with chamomile extract were developed with
Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402.
A previously unreported compound named pyrrocidine C was isolated from Lewia infectoria SNB-GTC2402 and identified by spectroscopic analysis and identified as a cis-substituted decahydrofluorene with a quaternary carbon at C-5 and opposite stereochemistry atC-8 corresponding to C-6 of p Pyrrocidines A and B.
Secondary Metabolites Isolated from the Amazonian Endophytic Fungus Diaporthe sp. SNB-GSS10.
We describe a Sabicea cinerea endophytic fungus closely related to Diaporthe pseudomangiferae that produces two known metabolites, mycoepoxydiene (1) and altiloxin A (2), as well as enamidin (3) and