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Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction.
Dasatinib (BMS-354825), a novel dual SRC/BCR-ABL kinase inhibitor, exhibits greater potency than imatinib mesylate (IM) and inhibits the majority of kinase mutations in IM-resistant chronic myeloidExpand
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Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.
The proliferating AR42J-B13 pancreatic cell line is known to respond to glucocorticoid treatment by producing foci of cells that express the liver-specific albumin gene. We demonstrate that this cellExpand
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Punish the parent not the progeny.
Chronic myeloid leukemia (CML) is sustained by a rare population of primitive, quiescent, BCR-ABL+ cells and represents an excellent example of a malignancy in which tumor-initiating cells representExpand
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Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16alpha-carbonitrile)] in rats chronically treated with carbon tetrachloride to causeExpand
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Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells
Gliotoxin has been shown to promote a reversal of liver fibrosis in an animal model of the disease although its mechanism of action in the liver is poorly defined. The effects of gliotoxin onExpand
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BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry
In chronic myeloid leukaemia, CD34+ stem/progenitor cells appear resistant to imatinib mesylate (IM) in vitro and in vivo. To investigate the underlying mechanism(s) of IM resistance, it is essentialExpand
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Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.
Pancreatic duodenal homeobox-1 (PDX-1) is a homeodomain protein that plays an important role in the development of the pancreas and in maintaining the identity and function of the islets ofExpand
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Glucose Regulates Islet Amyloid Polypeptide Gene Transcription in a PDX1- and Calcium-dependent Manner*
Islet amyloid polypeptide (IAPP) and insulin are expressed in the β-cells of the islets of Langerhans. They are co-secreted in response to changes in glucose concentration, and their mRNA levels areExpand
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Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.
BACKGROUND/AIMS Hepatic stellate cells are pivotal to fibrogenesis in the liver and many potential anti-fibrotic therapeutics are required to act on targets within hepatic stellate cells. The aim ofExpand
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Inhibitory effect of Pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters
Pax4 is a paired‐box transcription factor that plays an important role in the development of pancreatic β‐cells. Two Pax4 cDNAs were isolated from a rat insulinoma library. One contained theExpand
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