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The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.
The complete genomic sequence of Corynebacterium glutamicum ATCC 13032, well-known in industry for the production of amino acids, e.g. of L-glutamate and L-lysine was determined. The C. glutamicumExpand
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Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon.
Acetohydroxy acid synthase (AHAS) and isomeroreductase (IR) catalyze subsequent reactions in the flux of metabolites towards isoleucine, valine, leucine, and pantothenate. A 4,705-bp DNA fragmentExpand
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Handbook of Corynebacterium glutamicum
Part I: History A Short History of the Birth of the Amino Acid Industry in Japan, S. Kinoshita Part II: Taxonomy Corynebacterium Taxonomy, W. Liebl Part III: Genome, Plasmids and Gene Expression TheExpand
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Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
To determine the in vivo fluxes of the central metabolism we have developed a comprehensive approach exclusively based on the fundamental enzyme reactions known to be present, the fate of the carbonExpand
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A new type of transporter with a new type of cellular function: l‐lysine export from Corynebacterium glutamicum
We discovered that after deregulation of the l‐lysine biosynthesis in Corynebacterium glutamicum, l‐lysine accumulated in the cytosol and the efflux properties of this amino acid in mutants used forExpand
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A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level
We present a novel method for visualizing intracellular metabolite concentrations within single cells of Escherichia coli and Corynebacterium glutamicum that expedites the screening process ofExpand
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Linking Central Metabolism with Increased Pathway Flux: l-Valine Accumulation by Corynebacterium glutamicum
ABSTRACT Mutants of Corynebacterium glutamicum were made and enzymatically characterized to clone ilvD and ilvE, which encode dihydroxy acid dehydratase and transaminase B, respectively. These genesExpand
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Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum.
Twenty putative aminotransferase (AT) proteins of Corynebacterium glutamicum, or rather pyridoxal-5'-phosphate (PLP)-dependent enzymes, were isolated and assayed among others with L-glutamate,Expand
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Characterization of a Corynebacterium glutamicum Lactate Utilization Operon Induced during Temperature-Triggered Glutamate Production
ABSTRACT Gene expression changes of glutamate-producing Corynebacterium glutamicum were identified in transcriptome comparisons by DNA microarray analysis. During glutamate production induced by aExpand
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Expression control and specificity of the basic amino acid exporter LysE of Corynebacterium glutamicum.
LysE of Corynebacterium glutamicum belongs to a large new superfamily of translocators whose members are probably all involved in the export of small solutes. Here, the transcript initiation site ofExpand
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