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Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome: Results From the FINGER Brugada Syndrome Registry
TLDR
In the largest series of Brugada syndrome patients thus far, event rates in asymptomatic patients were low and gender, familial history of SCD, inducibility of ventricular tachyarrhythmias during electrophysiological study, and the presence of an SCN5A mutation were not predictive of arrhythmic events. Expand
Long-Term Prognosis of Individuals With Right Precordial ST-Segment–Elevation Brugada Syndrome
TLDR
A very low incidence of severe arrhythmic events, particularly in asymptomatic individuals, was found during follow-up and programmed electrical stimulation showed very little accuracy in predicting outcome. Expand
Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial
TLDR
Prophylactic VT ablation before defibrillator implantation seemed to prolong time to recurrence of VT in patients with stable VT, previous myocardial infarction, and reduced left-ventricular ejection fraction. Expand
Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3.
TLDR
In an intact rabbit heart model of LQT2 and LqT3 as well as in a computer model of the rabbit cardiac myocyte, inhibition of NCX is effective in preventing TdP due to a suppression of EADs, a reversion of action potential prolongation, and a reduction of dispersion of repolarization. Expand
Anterior-posterior versus anterior-lateral electrode positions for external cardioversion of atrial fibrillation: a randomised trial
TLDR
An anterior-posterior electrode position is more effective than the anterior-lateral position for external cardioversion of persistent atrial fibrillation and should be considered in clinical practice, for the design of defibrillation electrode pads, and when guidelines for cardioversions are updated. Expand
Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes
TLDR
It is shown that macrolide antibiotics lead to similar prolongation of repolarization but show a different proarrhythmic potential (erythromycin > clarithromycin • azithromyzin > azithrocin) than previously reported, which may be related to a rectangular pattern of action potential prolongation. Expand
Implant and Midterm Outcomes of the Subcutaneous Implantable Cardioverter-Defibrillator Registry: The EFFORTLESS Study.
TLDR
This registry demonstrates that the S-ICD fulfills predefined endpoints for safety and efficacy, and midterm performance rates on complications, inappropriate shocks, and conversion efficacy were comparable to rates observed in transvenous implantable cardioverter-defibrillator studies. Expand
Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3.
TLDR
Reduction of transmural dispersion of repolarization may be considered an important target for the prevention of TdP in patients with LQT3. Expand
Experimental models of torsade de pointes.
TLDR
It seems probable that the first beats of torsade occur due to early afterdepolarizations and triggered activity, and the development of subsequent beats is less clear. Expand
Amiodarone-Induced Postrepolarization Refractoriness Suppresses Induction of Ventricular Fibrillation
TLDR
Chronic amiodarone treatment prevents ventricular tachycardias by inducing PRR without much conduction slowing, thereby curtailing the initial part of APD restitution. Expand
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