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High acquisition and environmental contamination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital.
BACKGROUND Enterococcus faecium has rapidly emerged as a nosocomial pathogen worldwide, and the majority of these isolates belong to clonal complex-17 (CC17). In Europe, CC17 isolates are usuallyExpand
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Biomarker profiling of steroid-resistant acute GVHD in patients after infusion of mesenchymal stromal cells
We performed a prospective phase II study to evaluate clinical safety and outcome in 48 patients with steroid-refractory grade II–IV acute graft-versus-host disease (aGVHD) treated with mesenchymalExpand
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Potential Beneficial Effects of Cytomegalovirus Infection after Transplantation
Cytomegalovirus (CMV) infection can cause significant complications after transplantation, but recent emerging data suggest that CMV may paradoxically also exert beneficial effects in two specificExpand
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Prospective evaluation of sequential treatment of sclerotic chronic graft versus host disease with rituximab and nilotinib
Sclerotic chronic graft vs. host disease (cGVHD) still has a large impact on morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). We performed the firstExpand
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Cytomegalovirus Status and the Outcome of T Cell-Replete Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation.
Cytomegalovirus (CMV) serostatus of donor and recipient are frequently used in algorithms of donor selection, whereas the impact of CMV reactivation on transplantation-related mortality, leukemiaExpand
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Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile
Lotte E. van der Wagen ● Alberto Miranda-Bedate 2 ● Anke Janssen ● Febilla Fernando ● Nagesha Appukudige ● Sanne van Dooremalen ● Kasper Westinga ● Rick Admiraal ● Magdalena J. Lorenowicz ● GerwinExpand
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αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies.
We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral bloodExpand
Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT
Lymphocyte numbers need to be quite tightly regulated. It is generally assumed that lymphocyte production and lifespan increase homeostatically when lymphocyte numbers are low and, vice versa, returnExpand
Tyrosine kinase inhibitor levels matter in treating chronic GVHD
Key pointsWe observed a possible concentration effect relationship for nilotinib on resolution of chronic Graft versus Host disease.These data suggest therapeutic drug monitoring might be useful forExpand
Lymphocyte production and loss rates remain elevated post-autologous hematopoietic stem cell transplantation
Regulation of lymphocyte numbers is critical and under normal circumstances lymphocyte numbers remain relatively stable. It is generally assumed that when lymphocyte numbers decrease, the immuneExpand