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Synthesis of tritium‐labelled biologically active analogues of progesterone by selective hydrogenation of 16α,17α‐cyclohex‐3′‐en‐pregna‐1,4‐dien‐3,20‐dione
The procedure of selective hydrogenation with gaseous tritium of 16α,17α-cyclohex-3'-en-pregna-1,4-dien-3,20-dione (StO) has been elaborated, and isotopically labelledExpand
3- and 19-Oximes of 16α,17α-cyclohexanoprogesterone derivatives: Synthesis and interactions with progesterone receptor and other proteins
Series of 3- and 19-oximes of 16alpha,17alpha-cyclohexanoprogesterone derivatives (pregna-d'-pentaranes) have been synthesized with the aim of probing the surfaces of progesterone receptor's and twoExpand
[Species and tissue distribution specificity of proteins binding 16alpha,17alpha-cycloalkane derivatives of progesterone].
The binding of [3H]progesterone and [3H] 16 alpha,17 alpha-cycloalkanoprogesterones to proteins from rat, rabbit, and human uteri and other organs was studied. We found that 16 alpha,17Expand
Pregna-D'-pentaranes - a new class of active gestagenes.
A new class of modified progesterones with an additional ring in the 16 alpha , 17 alpha-position (pregna-D'-pentaranes) are described. Compounds containing 4- and 6-membered D'-ring (D'4- andExpand
Synthesis of [3H]-cycloalkanoprogesterones (pregna-d'-pentaranes) and study of their interaction with a progesterone receptor
In order to search target organs and to study the mechanism of the action of steroids with separated biological functions, tritium-labeled pregna-d'-pentaranes were synthesized by an originalExpand
Synthesis of 6(E)- and 6(Z)-(3-ethoxycarbonylpropyl)oximes of 16α,17α-cyclohexanopregn-4-ene-3,6,20-trione and study of their interaction with proteins of the rat uterine cytosol and blood serum
Abstract6(E)- and 6(Z)-(3-Ethoxycarbonylpropyl)- and -(3-carboxypropyl)oximes of 16α,17α-cyclohexanopregn-4-ene-3,6,20-trione were synthesized. The reactions of these ester ligands withExpand
Synthesis of 19-substituted steroids of the 16α,17α-cyclohexanopregnane series and study of their interactions with rat uterine cytosol and blood serum proteins
New 16α,17α-cyclohexanopregnanes (pregna-D′6-pentaranes) containing alkyl or heteroatomic substituents in position 19, namely, 19-methylidene-, 19-methyl-, 19-methoxyimino-, andExpand
Structural Features of Pregna-D′-pentaranes Determining Their Interaction with Three Rat Proteins
Competition of a number of progesterone 16α,17α-cycloalkane derivatives with 3H-labeled ligands for the binding sites of rat uterine progesterone receptor, uterine pentaranophilin, and blood serumExpand
16α,17α-Cycloalkane Derivatives of Progesterone Intensively Bind to a Rat Serum Protein
The interaction of 6α-methyl-[1,2-3H]16α,17α-cyclohexanoprogesterone with rat serum proteins has been studied. Specific binding of this ligand characterized by Kd = 0.36 ± 0.10 μM and concentrationExpand
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