• Publications
  • Influence
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
TLDR
Assessing the effects of morphine and cocaine on locomotor activity, behavioral sensitization, conditioned place preference, and striatal dopamine release in βarr2 knock-out (βarr2-KO) mice and their wild-type (WT) controls concluded that βarr 2 appears to play a more important role in the dopaminergic effects mediated by morphine than those induced by cocaine.
Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist.
TLDR
JDTic is the first potent kappa-selective opioid receptor antagonist not derived from an opiate class of compounds and fails to antagonize the analgesic effects of the selective MOP mu-opioid receptor agonists.
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.
TLDR
A rationale is presented to explain the seemingly paradoxical relationship between beta-arrestins and microOR regulation wherein morphine-like agonists fail to promote efficient internalization and resensitization of the receptor.
Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats.
TLDR
It is suggested that sympathoadrenal activity is involved in the suppressive effects of acute morphine treatment on the proliferative response of splenic T and B cells to Con A, lipopolysaccharide or ionomycin/phorbol myristate acetate.
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration.
TLDR
The asymmetrical cross-tolerance and cross-dependence between Mr 2033 and morphine, and the appearance of morphine-like signs during precipitated withdrawal, suggest thatMr 2033 is kappa receptor selective but not specific.
The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940)
TLDR
It is suggested that CB1 receptors are preferentially involved in the reinforcing effects of a complex sweet, as compared to a pure fat, reinforcer, and activation of the central CB1 system is sufficient to enhance Ensure and corn oil reinforcement.
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.
TLDR
It is indicated that training dose is an important determinant of the different levels of cross-substitution obtained between mu and kappa agonists, and that a greater pharmacological specificity of drug-induced discriminative stimuli can be obtained when relatively high training doses of mu andKappa opioid agonists are used to establish the discrimination.
Discriminative and analgesic effects of mu and kappa opioids: in vivo pA2 analysis.
TLDR
Analysis by pA2 was used to quantify interactions between the opioid antagonist quadazocine and several opioid agonists, suggesting that the discriminative stimulus and analgesic effects of kappa opioids agonists are mediated at the same opioid receptor type, which is different from the type of opioid receptor at which mu agonists produce their discriminatives stimulus and painkilling effects.
Kappa opioids in rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects.
TLDR
Doses of kappa agonists that produced ethylketazocine-appropriate responding were similar to doses that increased urine output and smaller than doses thatincreased tail-withdrawal latencies.
...
...