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Affinity-labelling corticoids I. Synthesis of 21-Chloroprogesterone, Deoxycorticosterone 21-(1-Imidazole) Carboxylate, 21-Deoxy-21-Chloro Dexamethasone, and Dexamethasone 21-Mesylate,
Abstract The efficient and unambiguous preparation of several C-21 substituted affinity-labelling corticoids are described. Included is an improved procedure for the preparation ofExpand
Steroid derivatives for electrophilic affinity labelling of glucocorticoid binding sites: interaction with the glucocorticoid receptor and biological activity.
To investigate the possible use of electrophilic affinity labelling for the characterization of glucocorticoid receptors, different chemically reactive derivatives of deoxycorticosteroneExpand
Palladium(0)-assisted synthesis of C-glycopyranosyl compounds.
Tetrakis(triphenylphosphine)palladium(0) effects the regio- and stereo-selective alkylation of 2-acetoxy-5,6-dihydro-2H-pyrans and 1-S-acetyl-1-thiohex-2-enopyranosides. Use of stabilized carbanionsExpand
Regioselective synthesis of substituted 1-thiohex-2-enopyranosides
A variety of 1-thiohex-2-enopyranosides have been prepared from their corresponding 3-O-methyl- or 3-O-acetylglycals by using trimethylsilyl thiols catalyzed by BF/sub 3/ etherate. This method isExpand
Synthetic approaches to brevianamides A and B I. Preparation of 4-p-methoxybenzyl-5-(1′-carbomethoxy-2′-[1″, 1″-dimethylallyl-2′, 3′dihydroindole]methylidene)-1, 2-L-pyrolidinopiperazine-3, 6-dione
Abstract Using an ester enolate Claisen rearrangement to prepare 1-carbomethoxy-2-(1′, 1′-dimethylallyl)-2, 3-dihydroindole-2-carboxylic acid followed by condensation withExpand
Synthetic approaches to bicyclomycin I. Prepration of monocylic intermediates by retrograde Michael cleavage of 6-alkyl-6-methoxyhexahydro-3H-thiazolo [3,4-a]pyrazine-5,8-diones.
Abstract The syntheses of N-protected-3-(hydroxypropyl)-3-methoxy-6-alkylidine piperazine-2,5-diones are described, in relation to an approach to bicyclomycin. A chemoselective Grignard reaction andExpand