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The global impact of pre-eclampsia and eclampsia.

  • L. Duley
  • Medicine
    Seminars in Perinatology
  • 1 June 2009
Although it is a low cost effective treatment, magnesium sulfate is not available in all low and middle income countries; scaling up its use for eClampsia and severe preeclampsia will contribute to achieving the Millennium Development Goals.
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Alternative versus standard packages of antenatal care for low-risk pregnancy.

Reduced visits were associated with a reduction in admission to neonatal intensive care that was borderline for significance, and there was no clear difference between the groups for the other secondary clinical outcomes.
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Antiplatelet agents for preventing pre-eclampsia and its complications.

Antiplatelet agents, largely low-dose aspirin, have moderate benefits when used for prevention of pre-eclampsia and its consequences.
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Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.

Providing additional placental blood to the preterm baby by either delaying cord clamping for 30 to 120 seconds, rather than early clamping, seems to be associated with less need for transfusion, better circulatory stability, less intraventricular haemorrhage (all grades) and lower risk for necrotising enterocolitis.
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Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

The average risk of high blood pressure was reduced with calcium supplementation compared with placebo and the composite outcome maternal death or serious morbidity was reduced, but there was an anomalous increase in the risk of HELLP.
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Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.

There is a halving in the risk of developing severe hypertension associated with the use of antihypertensive drug(s) and other outcomes were only reported by a small proportion of studies, and there were no clear differences in any other outcomes.
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Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.

This Cochrane Review is a further update of a review first published in 2004 and updated in 2012 and includes forty-eight studies, with data available from 40 studies involving 4884 babies and their mothers.
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Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.

Magnesium sulphate more than halves the risk of eclampsia, and probably reduces therisk of maternal death, and does not improve outcome for the baby, in the short term.
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Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial

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Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean

  • L. Duley
  • Political Science, Medicine
    British Journal of Obstetrics and Gynaecology
  • 1 July 1992
Estimates of maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean are presented and strategies to prevent these deaths are discussed.
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