• Publications
  • Influence
European S3‐Guidelines on the systemic treatment of psoriasis vulgaris
TLDR
Phototherapy represents a safe and very effective treatment option for moderate to severe forms of psoriasis vulgaris and has a good cost-benefit ratio, but the potentially significant costs for, and time required of, the patient must be considered. Expand
Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells1
TLDR
It is found that CD4+CD25high T cells are overrepresented in metastatic lymph nodes (LNs) with a 2-fold increased frequency compared with both tumor-free LNs and autologous PBMCs, which could explain the poor clinical response of cancer patients under immunotherapeutic protocols. Expand
Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION)
TLDR
This data indicates that once-weekly dosing with adalimumab is a safe and effective treatment for moderate to severe chronic plaque psoriasis in women with atypical immune response to chemotherapy. Expand
Risk of malignancies in psoriasis patients treated with cyclosporine: a 5 y cohort study.
TLDR
Treatment of psoriasis with cyclosporine is associated with an increased risk of nonmelanoma skin cancer and exposure to psoralen and ultraviolet A and to other immunosuppressants was shown to contribute to the overall risk. Expand
Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis.
TLDR
The key role played by NF-kappaB in the resistance of CTCL to apoptosis is demonstrated and bortezomib might be useful for the treatment of patients with advanced stages of C TCL refractory to standard antineoplastic chemotherapy. Expand
Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma.
TLDR
This study suggests that, similarly to vulvar carcinoma, penile SCC occurs in association with two types of penile lesions: undifferentiated (or bowenoid) PIN and LS-linked differentiated PIN and/or SH. Expand
European patient perspectives on the impact of psoriasis: the EUROPSO patient membership survey
TLDR
A Europe‐wide survey examining quality of life and patients’ perspectives on treatment and their disease concluded that Psoriasis patients believe that adequate treatment and awareness of the risks and benefits of treatment should be considered. Expand
Ciclosporin in psoriasis clinical practice: an international consensus statement
TLDR
The main recommendations for the use of ciclosporin in the management of psoriasis are intermittent short courses (average of 12 weeks duration) and adherence to treatment guidelines substantially reduces the risk of adverse events. Expand
Accuracy of standard dermoscopy for diagnosing scabies.
TLDR
Standard DS with a handheld DS is a useful tool for diagnosing scabies, with high sensitivity, even in inexperienced hands, and greatly enhances clinical skills for making treatment decisions. Expand
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