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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
It is reported that overexpression of sirtuin 1 (Sirt1), a mediator of the beneficial metabolic effects of calorie restriction, protects neurons against mutantHTT toxicity, whereas reduction of Sirt1 exacerbates mutant HTT toxicity.
Aspergiolide A, a novel anthraquinone derivative with naphtho [1,2,3 -de]chromene -2,7 -dione skeleton isolated from a marine-derived fungus Aspergillus glaucus
Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.
Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseum…
New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp.
Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17.
Two novel sorbicillinoids combining a bicyclo-octane moiety with a 2-methoxyphenol moiety were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17 and exhibited activities against influenza virus A (H1N1).
Isocoumarin derivatives from the sea squirt-derived fungus penicillium stoloniferum QY2-10 and the halotolerant fungus penicillium notatum B-52
Two isocoumarin derivatives, stoloniferol A and B, and a known 5a, 8a-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3 β-ol were isolated from the ethyl acetate extract of the sea squirt-derived fungus and showed cytotoxicity against P388 cells.
Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities
Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus.
- L. Du, T. Zhu, Hongbing Liu, Yuchun Fang, Weiming Zhu, Q. Gu
- ChemistryJournal of natural products
- 6 November 2008
Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures…
Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase IIα inhibitor.
Tricitrinol B (4) represents a novel class of topo IIα-inhibitory skeletons for developing new chemotherapeutic agents and shows extensive cytotoxicity in 17 tumor cells with comparable low-micromolar IC(50) values (1-10 μM) and potential antimultidrug resistance capabilities.
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
While antiproliferative activity was observed at higher concentrations, the sesquiterpene quinones possessing a 2-hydroxy-5-methoxy-1,4-benzoquinone moiety activated Hif-1 and increased the expression of HIF-1 target gene vascular endothelial growth factor (VEGF) in T47D cells.