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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
We show that overexpression of sirtuin 1 (Sirt1), a mediator of the beneficial metabolic effects of calorie restriction, protects neurons against mutant HTT toxicity and attenuates mutant-HTT–mediated metabolic abnormalities in Huntington's disease mice. Expand
Aspergiolide A, a novel anthraquinone derivative with naphtho [1,2,3 -de]chromene -2,7 -dione skeleton isolated from a marine-derived fungus Aspergillus glaucus
Aspergiolide A (1), an anthraquinone derivative with naphtho[1,2,3-de]chromene-2,7-dione skeleton, has been isolated from cultures of a marine-derived fungus Aspergillus glaucus. The structure andExpand
Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.
Three new quinazoline alkaloids, aurantiomides A (1), B (2), and C (3), along with the known metabolite anacine (4) were isolated from the sponge-derived fungus strain Penicillium aurantiogriseumExpand
Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus.
Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structuresExpand
Diketopiperazine alkaloids from a deep ocean sediment derived fungus Penicillium sp.
Five new diketopiperazine alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derivedExpand
Isocoumarin derivatives from the sea squirt-derived fungus penicillium stoloniferum QY2-10 and the halotolerant fungus penicillium notatum B-52
Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5a, 8a-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3 β-ol (3), and a known dihydrocitrinone (4) were isolated from the ethylExpand
Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17.
Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungusExpand
New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp.
Four new alkaloids, including two new meleagrin analogs, meleagrins B (2) and C (3), and two new diketopiperazines, roquefortines F (5) and G (6), together with six new diterpenes, conidiogenones B–GExpand
Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57.
In order to search for structurally novel and bioactive natural compounds from microorganisms, a halotolerant fungal strain, Penicillium citrinum B-57, which mainly produces citrinin derivatives, wasExpand