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Silicified Horodyskia and Palaeopascichnus from upper Ediacaran cherts in South China: tentative phylogenetic interpretation and implications for evolutionary stasis
Horodyskia is one of the earliest known macroscopic life forms, with a fossil record dating from c. 1.4 Ga. Palaeopascichnus represents a key Ediacaran element with world-wide distribution. However,Expand
Basal Cambrian Microfossils from the Yangtze Gorges Area (South China) and the Aksu Area (Tarim Block, Northwestern China)
Abstract The basal Cambrian marks the beginning of an important chapter in the history of life. However, most paleontological work on the basal Cambrian has been focused on skeletal animal fossils,Expand
Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells
Background/Aims: Resistance of leukemia stem cells (LSCs) to chemotherapy in patients with acute myeloid leukemia (AML) causes relapse of disease. Hedgehog (Hh) signaling plays a critical role in theExpand
Epigenetic Enhancement of Brain-Derived Neurotrophic Factor Signaling Pathway Improves Cognitive Impairments Induced by Isoflurane Exposure in Aged Rats
Isoflurane-induced cognitive impairments are well documented in animal models; yet, the molecular mechanisms remain largely to be determined. In the present study, 22-month-old male Sprague-DawleyExpand
Class I Histone Deacetylase Inhibitor Valproic Acid Reverses Cognitive Deficits in a Mouse Model of Septic Encephalopathy
Accumulating evidence suggests that histone deacetylase inhibitor exert neuroprotective effects in animal models of neurological diseases. We investigated for the first time whether class I histoneExpand
Follicular helper T cells promote the effector functions of CD8+ T cells via the provision of IL‐21, which is downregulated due to PD‐1/PD‐L1‐mediated suppression in colorectal cancer
Abstract Recent studies have demonstrated that higher expression of follicular helper T cell (Tfh)‐associated genes is associated with better prognosis in breast cancer and colorectal cancer (CRC),Expand
ITER electrical distribution system
ITER is a representative prototype of a fusion power plant. It contains most of the features and systems that are anticipated in a fusion reactor and will produce substantial fusion power (500 MW)Expand
Cyclosporin A Improves Pregnancy Outcome by Promoting Functions of Trophoblasts and Inducing Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings in the Mouse1
Abstract The embryo expresses paternal antigens foreign to the mother, and therefore has been viewed as a natural allograft. Cyclosporin A (CsA) is an immunosuppressant for preventing allograftExpand
Cyclosporin A increases expression of matrix metalloproteinase 9 and 2 and invasiveness in vitro of the first-trimester human trophoblast cells via the mitogen-activated protein kinase pathway.
BACKGROUND Cyclosporin A (CsA) is an immunosuppressent which is used for preventing allograft rejection. Little is known, however, about the effect of CsA on the materno-fetal relationship. Our aimExpand
PD-L1 expression and CD274 gene alteration in triple-negative breast cancer: implication for prognostic biomarker
PurposeTo estimate the therapeutic potential of PD-L1 inhibition in breast cancer, we evaluated the prevalence and significance of PD-L1 protein expression with a validated antibody and CD274 geneExpand