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Tea polyphenols as inhibitors of mutagenicity of major classes of carcinogens.
- J. Weisburger, Y. Hara, L. Dolan, F. Luo, B. Pittman, E. Zang
- Chemistry, MedicineMutation research
- 4 November 1996
Polyphenols sharply decreased the mutagenicity of a number of aryl- and heterocyclic amines, of aflatoxin B1, benzo[a]pyrene, 1,2-dibromoethane, and more selectively, of 2-nitropropane, all involving an induced rat liver S9 fraction.
Inhibition of PhIP mutagenicity by caffeine, lycopene, daidzein, and genistein.
It is found that PhIP is a good substrate found in several human foods to determine the protective effect of phytochemicals from vegetables, and beverages, and caffeine displayed effective dose-related inhibition of the mutagenicity of PhIP.
Genotoxicity and carcinogenicity in rats and mice of 2-amino-3,6-dihydro-3-methyl-7H-imidazolo[4,5-f]quinolin-7- one: an intestinal bacterial metabolite of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline.
- J. Weisburger, A. Rivenson, +7 authors M. Bashir
- Biology, MedicineJournal of the National Cancer Institute
- 5 January 1994
7-OHIQ is not genotoxic, for to be so classified it must be definitely positive in both the Ames and Williams tests, and it is not carcinogenic, in marked contrast to IQ and NMU.
Secondary nitroalkanes: induction of DNA repair in rat hepatocytes, activation by aryl sulfotransferase and hepatocarcinogenicity of 2-nitrobutane and 3-nitropentane in male F344 rats.
In a carcinogenicity assay using male F344 rats, the secondary nitroalkanes, 2-nitrobutane and 3-nitropentane, produced a highly significant incidence of hepatocarcinoma with metastases to the lungs, whereas the primary nitroalksane, 1-nitRObutane, was not carcinogenic.
Evaluation of the mutagenic effect of the new fungicide trimorphamide.
- M. Vargová, H. Poláková, S. Podstavková, A. Sisková, L. Dolan
- Biology, MedicineMutation research
- 1 August 1980
Under the testing conditions the trimorphamide concentrations used did not show any mutagenic effect upon Drosophila, compared with the controls, and under the conditions of the cytogenetic analysis, no significant increase in the frequency of chromosomal abnormalities in mouse bone marrow or in human peripheral lymphocyte was observedCompared with the group of controls.
The mutagenic effect of the new insecticide and acaricide pyridathion.
There was no significant increase in the frequency of chromosomal abnormalities in bone marrow of mice of rats, or in human peripheral lymphocytes in vitro, compared with controls, and the insecticide did not exert any mutagenic effect on the bacteria.
Containment of procedure-associated aerosols by an extractor tent: effect on nebulized drug particle dispersal
Results show the extractor tent was completely effective in preventing airborne spread of drug particles of respirable size from nebulised therapy, which suggests extractor tents of this kind would be efficacious in prevent airborne infection from aerosol-generating procedures during the COVID-19 pandemic.
Prevention of Nebulised Drug Dispersal using an Extractor Tent
Testing the efficacy of an extractor tent on reducing detectable aerosols from nebulised bronchodilator drugs by continuously monitoring a room outside a tent containing a nebuliser showed 100 % efficacy, suggesting that extractor tents can prevent spread of drug particles from neBulised therapy.