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AVE 0991, a Nonpeptide Mimic of the Effects of Angiotensin-(1–7) on the Endothelium
- G. Wiemer, L. Dobrucki, F. Louka, T. Malinski, H. Heitsch
- Chemistry, Medicine
- 1 December 2002
AVE 0991 efficiently mimics the effects of Ang-(1–7) on the endothelium, most probably through stimulation of a specific, endothelial Ang-( 1–7)-sensitive binding site causing kinin-mediated activation of endothelial NO synthase. Expand
Noninvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Postinfarction Remodeling
This novel noninvasive targeted MMP-targeted radiotracer imaging approach holds significant diagnostic potential for in vivo localization of MMP activation and tracking of M MP-mediated post-MI remodeling. Expand
Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo.
This study suggests that AS1411 aptamer-functionalized liposomes can recognize nucleolin overexpressed on MCF-7 cell surface, and therefore enable drug delivery with high specificity and selectivity and improve antitumor efficacy against xenograft MCf-7 breast tumors in athymic nude mice. Expand
Investigating the optimal size of anticancer nanomedicine
- L. Tang, X. Yang, +15 authors Jianjun Cheng
- Materials Science, Medicine
- Proceedings of the National Academy of Sciences
- 14 October 2014
Among the three NCs investigated, the 50-nm NC shows the highest tumor tissue retention integrated over time, which is the collective outcome of deep tumor tissue penetration and efficient cancer cell internalization as well as slow tumor clearance, and thus, the highest efficacy against both primary and metastatic tumors in vivo. Expand
Third-Generation &bgr;-Blockers Stimulate Nitric Oxide Release From Endothelial Cells Through ATP Efflux: A Novel Mechanism for Antihypertensive Action
These results demonstrate for the first time that nebivolol and carvedilol induce relaxation of renal glomerular microvasculature through ATP efflux with consequent stimulation of P2Y-purinoceptor–mediated NO release from GECs. Expand
PET and SPECT in cardiovascular molecular imaging
An overview of selected molecular-based single photon emission CT (SPECT) and PET imaging strategies for the evaluation of cardiovascular disease and potential future targeted methods of evaluating critical molecular processes, such as atherosclerosis, ventricular remodeling after myocardial infarction, and ischemia-associated angiogenesis are provided. Expand
Statin-stimulated nitric oxide release from endothelium.
- L. Dobrucki, L. Kalinowski, I. Dobrucki, T. Malinski
- Chemistry, Medicine
- Medical science monitor : international medical…
- 1 July 2001
The tested statins demonstrate variable potency to enhance the NO/O2- concentration ratio after stimulation of NOS, resulting in an increase of NO bioavailability in endothelial cells. Expand
Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis.
- Nadia Hedhli, L. Dobrucki, +5 authors K. Russell
- Biology, Medicine
- Cardiovascular research
- 1 March 2012
Endothelial production of NRG is required for angiogenesis and arteriogenesis induced by ischaemic injury and exogenous administration of rNRG can enhance this process, suggesting a potential role for NRG in vascular disease. Expand
Tissue‐engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel
- N. Hibino, G. Villalona, +15 authors C. Breuer
- Medicine, Biology
- FASEB journal : official publication of the…
- 12 May 2011
This work again finds that seeded BMMCs are lost, declining to 0.02% at 14 d, concomitant with host macrophage invasion, and demonstrates using sex‐mismatched chimeric hosts that bone marrow is not a significant source of endothelial or smooth muscle cells that comprise the neovessel. Expand
Nitric oxide as a second messenger in parathyroid hormone-related protein signaling.
Based on direct in situ measurements, it is reported here for the first time that the human PTH/PTHrP receptor analogs, hPTH(1--34) and hP THrP(1-34), stimulate NO release from a single endothelial cell. Expand