L. Dobbs

Publications99
h-index38
Citations6,380
Highly Influential Citations184
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Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells.
Deep inflation of the lung stimulates surfactant secretion by unknown mechanisms. The hypothesis that mechanical distension directly stimulates type II cells to secrete surfactant was tested by… Expand
  • 486
  • 19
[Ca(2+)](i) oscillations regulate type II cell exocytosis in the pulmonary alveolus.
Pulmonary surfactant, a critical determinant of alveolar stability, is secreted by alveolar type II cells by exocytosis of lamellar bodies (LBs). To determine exocytosis mechanisms in situ, we imaged… Expand
  • 143
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An improved method for isolating type II cells in high yield and purity.
A method has been developed for isolating alveolar type II cells by digesting lung tissue with elastase and "panning" the resultant cell suspension on plates coated with IgG. This method provides… Expand
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Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport.
Efficient gas exchange in the lungs depends on regulation of the amount of fluid in the thin (average 0.2 mum) liquid layer lining the alveolar epithelium. Fluid fluxes are regulated by ion transport… Expand
  • 171
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Isolation and culture of alveolar type II cells.
  • L. Dobbs
  • Biology, Medicine
  • The American journal of physiology
  • 1 April 1990
The alveolar type II cell performs many important functions within the lung, including regulation of surfactant metabolism, ion transport, and alveolar repair. Because type II cells comprise only 15%… Expand
  • 380
  • 10
Monoclonal antibodies specific to apical surfaces of rat alveolar type I cells bind to surfaces of cultured, but not freshly isolated, type II cells.
The alveolar surface of the lung is lined by two classes of epithelial cells, type I and type II cells. Type I cells cover more than 97% of the alveolar surface. Although this cell type is felt to be… Expand
  • 243
  • 10
Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis
Transport of lung liquid is essential for both normal pulmonary physiologic processes and for resolution of pathologic processes. The large internal surface area of the lung is lined by alveolar… Expand
  • 244
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Changes in biochemical characteristics and pattern of lectin binding of alveolar type II cells with time in culture.
When cultured on plastic culture dishes for several days, alveolar type II cells gradually lose both their morphologic and biochemical identifying characteristics. Although type II cells cultured on… Expand
  • 186
  • 7
Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung.
Water permeability measured between the airspace and vasculature in intact sheep and mouse lungs is high. More than 95% of the internal surface area of the lung is lined by alveolar epithelial type I… Expand
  • 213
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Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation.
  • L. Dobbs, R. Mason
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 March 1979
It is unclear what factors control the secretion of pulmonary surface active material from alveolar type II cells in vivo. Other workers have suggested that cholinergic stimuli, adrenergic stimuli,… Expand
  • 316
  • 5