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Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction.
Blood vessel networks expand in a 2-step process that begins with vessel sprouting and is followed by vessel anastomosis. Vessel sprouting is induced by chemotactic gradients of the vascular… Expand
VEGF Signaling through Neuropilin 1 Guides Commissural Axon Crossing at the Optic Chiasm
Summary During development, the axons of retinal ganglion cell (RGC) neurons must decide whether to cross or avoid the midline at the optic chiasm to project to targets on both sides of the brain. By… Expand
Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development. Biochemical evidence supports a model for… Expand
The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins
- Alessandro Fantin, Q. Schwarz, K. Davidson, E. Normando, L. Denti, C. Ruhrberg
- Biology, Medicine
- 1 October 2011
Neuropilin 1 (NRP1) is a transmembrane glycoprotein that is essential for blood vessel development in vertebrates. Best known for its ability to bind members of the vascular endothelial growth factor… Expand
Erythro-myeloid progenitors contribute endothelial cells to blood vessels
- A. Plein, Alessandro Fantin, L. Denti, J. Pollard, C. Ruhrberg
- Chemistry, Medicine
- 26 September 2018
The earliest blood vessels in mammalian embryos are formed when endothelial cells differentiate from angioblasts and coalesce into tubular networks. Thereafter, the endothelium is thought to expand… Expand
Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation.
- A. Plein, A. Calmont, +4 authors C. Ruhrberg
- Medicine, Biology
- The Journal of clinical investigation
- 1 July 2015
In mammals, the outflow tract (OFT) of the developing heart septates into the base of the pulmonary artery and aorta to guide deoxygenated right ventricular blood into the lungs and oxygenated left… Expand
Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization—Brief Report
- Sidath E. Liyanage, Alessandro Fantin, +8 authors C. Ruhrberg
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 23 December 2015
Objective— Ocular neovascularization (ONV) is a pathological feature of sight-threatening human diseases, such as diabetic retinopathy and age-related macular degeneration. Macrophage depletion in… Expand
VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
The vascular endothelial growth factor (VEGFA, VEGF) regulates neurovascular patterning. Alternative splicing of the Vegfa gene gives rise to three major isoforms termed VEGF121, VEGF165 and VEGF189.… Expand
NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis.
Neuropilin (NRP) 1 is a receptor for the vascular endothelial growth factor (VEGF)-A and is essential for normal angiogenesis. Previous in vitro experiments identified NRP1 interactions with VEGF-A's… Expand
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells
- C. Raimondi, Alessandro Fantin, Anastasia Lampropoulou, L. Denti, Anissa Chikh, C. Ruhrberg
- Biology, Medicine
- The Journal of experimental medicine
- 2 June 2014
Neuropilin 1 regulates angiogenesis in a VEGF-independent manner via association with ABL1, suggesting that Imatinib represents a novel opportunity for anti-angiogenic therapy.