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Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.
CONTEXT Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidityExpand
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The risks and benefits of long‐term use of hydroxyurea in sickle cell anemia: A 17.5 year follow‐up
A randomized, controlled clinical trial established the efficacy and safety of short‐term use of hydroxyurea in adult sickle cell anemia. To examine the risks and benefits of long‐term hydroxyureaExpand
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An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.
BACKGROUND In adults with sickle cell disease (SCD), an increased tricuspid regurgitant velocity (TRV) measured by Doppler echocardiography, an increased serum N-terminal pro-brain natriureticExpand
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Religiosity/Spirituality and Pain in Patients With Sickle Cell Disease
Religion/spirituality has been identified by individuals with sickle cell disease (SCD) as an important factor in coping with stress and in determining quality of life. Research has demonstratedExpand
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Moderate chronic pain, weight and dietary intake in African-American adult patients with sickle cell disease.
In this exploratory study, we evaluated weight status and dietary intake patterns during painful episodes in adult patients with SCD. Specifically, we explored the relation between pain severity andExpand
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Depression, suicidal ideation, and attempts in black patients with sickle cell disease.
There is a strong relationship between suicidal ideation, suicide attempts, and depression. Rates of successful suicides are relatively high among the chronically ill compared to other populationsExpand
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The association of optimism and perceived discrimination with health care utilization in adults with sickle cell disease.
OBJECTIVE We evaluated the effect of perceived discrimination, optimism, and their interaction on health care utilization among African American adults with sickle cell disease (SCD). METHODSExpand
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Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible.
Despite increasing information about the mechanism of action of cyclosporine A (CsA), little is known about the way lymphocytes recover from CsA. Recovery is central to understanding theExpand
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Differences in platelet alpha-granule release between normals and immune thrombocytopenic patients and between young and old platelets.
The risk of serious bleeding in patients with immune thrombocytopenic purpura (ITP) appears to be less than in comparably thrombocytopenic patients with megakaryocytic hypoplasia. It has beenExpand
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Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia.
The Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) was a randomized double-blind placebo-controlled trial to test whether hydroxyurea could reduce the rate of painful crises in adultsExpand
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