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Folate levels and neural tube defects. Implications for prevention.
Using data from a recent case-control study, a woman's risk of having a child with a neural tube defect (NTD) was found to be associated with early pregnancy red cell folate levels in a continuous
Hyperhomocysteinemia: an independent risk factor for vascular disease.
TLDR
Hyperhomocysteinemia is an independent risk factor for vascular disease, including coronary disease, and in most instances is probably due to cystathionine beta-synthase deficiency.
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.
TLDR
An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia, and compared with nonusers of vitamin supplements, the small number of subjects taking such vitamins appeared to have a substantially lower risk ofascular disease, a proportion of which was attributable to lower plasma homocy steine levels.
Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.
TLDR
Plasma folate and plasma B12 were independent risk factors for NTDs, suggesting that the enzyme methionine synthase is involved directly or indirectly in the aetiology.
Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study.
TLDR
The hypothesis that diet is related, albeit weakly, to the development of coronary heart disease is supported.
Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis.
TLDR
This meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations.
Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.
TLDR
Lower levels of folate and vitamin B6 confer an increased risk of atherosclerosis, independent of conventional risk factors and for folate was explained in part by increased homocysteine levels.
A randomised trial of low dose folic acid to prevent neural tube defects. The Irish Vitamin Study Group.
TLDR
Findings are consistent with those of the Medical Research Council (MRC) trial which demonstrated the efficacy of folic acid in preventing recurrence of NTDs and they raise the possibility that folic Acid may be protective at a much lower dosage than that used in the MRC trial.
Male prevalence for reading disability is found in a large sample of Black and White children free from ascertainment bias
TLDR
There is a clear sex bias toward males for the incidence of reading disabilities, irrespective of race, severity of disability, or exclusion of children with attentional disturbances or high activity levels.
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