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β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.
- L. D. Roberts, Pontus Boström, +20 authors R. Gerszten
- Biology, Medicine
- Cell metabolism
- 7 January 2014
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to… Expand
Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome.
The complex aetiology of type 2 diabetes makes effective screening, diagnosis and prognosis a substantial challenge for the physician. The rapidly developing area of metabolomics, which uses… Expand
Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
Background— Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain… Expand
Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway
Inorganic nitrate was once considered an oxidation end product of nitric oxide metabolism with little biological activity. However, recent studies have demonstrated that dietary nitrate can modulate… Expand
- L. D. Roberts, A. Souza, R. Gerszten, C. Clish
- Medicine, Chemistry
- Current protocols in molecular biology
- 1 April 2012
The metabolome is the terminal downstream product of the genome and consists of the total complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or organism.… Expand
A matter of fat: an introduction to lipidomic profiling methods.
- L. D. Roberts, G. McCombie, C. Titman, J. Griffin
- Chemistry, Medicine
- Journal of chromatography. B, Analytical…
- 15 August 2008
In recent years, lipidomics or lipid profiling, an extension of metabolomics where the lipid complement of a cell, tissue or organism is measured, has been the recipient of increasing attention as a… Expand
Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism
BackgroundInsulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid… Expand
Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release
Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on… Expand
Metabolic phenotyping of a model of adipocyte differentiation.
- L. D. Roberts, S. Virtue, A. Vidal-Puig, A. Nicholls, J. Griffin
- Biology, Medicine
- Physiological genomics
- 1 October 2009
The 3T3-L1 murine cell line is a robust and widely used model for the study of adipogenesis and processes occurring in mature adipocytes. The fibroblastic like cells can be induced by hormones to… Expand
PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.
Virtually all organisms seek to maximize fitness by matching fuel availability with energy expenditure. In vertebrates, glucose homeostasis is central to this process, with glucose levels finely… Expand