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Beyond Palliative Mastectomy in Inflammatory Breast Cancer—A Reassessment of Margin Status
TLDR
This study suggests that in patients with inflammatory breast cancer and nonmetastatic disease, an aggressive surgical approach may be justified with the goal of a negative surgical margin, and achievement of this local control is associated with a better overall outcome for this subset of patients.
Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?
TLDR
Nearly half of patients with breast cancer with a P/LP variant with clinically actionable and/or management guidelines in development are missed by current testing guidelines, suggesting that all patients with a diagnosis of breast cancer undergo expanded panel testing.
Oligonucleotide modulation of multidrug resistance.
Primary lymphoepithelioma-like carcinoma of the lung in a child. Report of an Epstein-Barr virus-related neoplasm.
TLDR
This work presents the first reported case of primary pulmonary LEC in a child, an undifferentiated carcinoma with pronounced lymphocytic infiltration, seen in the nasopharynx as well as in other areas.
Multigene Panel Testing Detects Equal Rates of Pathogenic BRCA1/2 Mutations and has a Higher Diagnostic Yield Compared to Limited BRCA1/2 Analysis Alone in Patients at Risk for Hereditary Breast
TLDR
Multigene panel testing detects pathogenic BRCA1/2 mutations at equivalent rates as limited testing and increases the diagnostic yield and patients at risk for hereditary breast cancer can safely benefit from up-front, more efficient, multigenePanel testing.
Anti-oncogene ribozymes for cancer gene therapy.
Preliminary Results in 173 Breast Cancer Patients Treated with Post‐Lumpectomy MammoSite Single‐Lumen Brachytherapy or Multi‐Catheter Brachytherapy
TLDR
Long‐term follow‐up is needed to determine if the delivery of a lower radiation dose to the ribs will translate into a lower incidence of rib pain and fractures and whether the results with MammoSite and multi‐catheter brachytherapy can be compared.
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