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Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Objective. —To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. Data… Expand
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study
Background— Visceral adipose tissue (VAT) compartments may confer increased metabolic risk. The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in… Expand
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
OBJECTIVE To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. DATA… Expand
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of… Expand
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have… Expand
Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies
- F. Rivadeneira, U. Styrkarsdottir, +32 authors A. Uitterlinden
- Biology, Medicine
- Nature Genetics
- 17 September 2009
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association… Expand
Risk Factors for Longitudinal Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study
- M. Hannan, D. Felson, +4 authors D. Kiel
- Journal of bone and mineral research : the…
- 1 April 2000
Few studies have evaluated risk factors for bone loss in elderly women and men. Thus, we examined risk factors for 4‐year longitudinal change in bone mineral density (BMD) at the hip, radius, and… Expand
Heart rate and cardiovascular mortality: the Framingham Study.
The relation of resting heart rate on biennial ECG examinations to mortality rates over 30 years of follow-up of the Framingham cohort was examined based on 1876 total deaths and 894 cardiovascular… Expand
Genotype score in addition to common risk factors for prediction of type 2 diabetes.
- J. Meigs, P. Shrader, +8 authors L. Cupples
- The New England journal of medicine
- 20 November 2008
BACKGROUND Multiple genetic loci have been convincingly associated with the risk of type 2 diabetes mellitus. We tested the hypothesis that knowledge of these loci allows better prediction of risk… Expand