• Publications
  • Influence
Gastroprotection and effect of the simultaneous administration of Cuachalalate (Amphipterygium adstringens) on the pharmacokinetics and anti‐inflammatory activity of diclofenac in rats
TLDR
The experimental findings in rats suggest that CME at doses lower than 100 mg kg−1 protects the gastric mucosa from the damage induced by diclofenac sodium without altering either the anti‐inflammatory activity or the pharmacokinetics of this NSAID. Expand
Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats
TLDR
Dillapiole was identified as the most active compound in this extract of P. pellucida using an ethanol-induced gastric ulcer experimental rat model and suggests that the gastroprotective mechanism of action of dillapIOle does not involve prostaglandins, NO or sulfhydryl groups. Expand
Bioavailability of a generic of the immunosuppressive agent mycophenolate mofetil in pediatric patients
TLDR
The two formulations exhibited similar drug content and dissolution profiles, as well as comparable mycophenolic acid plasma levels in an end‐stage renal failure population, and there were no statistically significant differences between formulations in bioavailability parameters. Expand
Gastroprotective activity of caryophyllene oxide: the role of nitric oxide, prostaglandins and sulfhydryls.
Article history: Received on: 14/08/2014 Revised on: 27/08/2014 Accepted on: 11/09/2014 Available online: 27/09/2014 The present study was carried out to evaluate the gastroprotective effect ofExpand
A novel, simple and inexpensive procedure for the simultaneous determination of iopamidol and p-aminohippuric acid for renal function assessment from plasma samples in awake rats.
TLDR
In conclusion, the method here described is a simple and reliable procedure, for the simultaneous and time-saving determination of GFR and TS from plasma samples in the conscious rat. Expand
Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls
TLDR
The mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds, and was more potent than carbenoxolone, the reference drug. Expand
L-arginine reverses alterations in drug disposition induced by spinal cord injury by increasing hepatic blood flow.
TLDR
It is suggested that L-arginine is able to reverse SCI-induced alterations in phenacetin pharmacokinetics due to an impaired hepatic MVBF, likely by increased nitric oxide synthesis leading to vasodilation. Expand
Understanding drug disposition alterations induced by acute spinal cord injury: role of injury level and route of administration for agents submitted to extensive liver metabolism.
TLDR
It is demonstrated that acute SCI significantly alters the pharmacokinetics of high extraction drugs, and the outcome of such alterations depends on the level of SCI and on the route of administration. Expand
Limustin®, a non‐innovator tacrolimus formulation, yields reduced drug exposure in pediatric renal transplant recipients
TLDR
Limustin® exhibits pharmaceutical characteristics dissimilar to the innovator that likely explain the reduced tacrolimus exposure in children and it is considered Limustin®, is not adequate for pediatric use. Expand
...
1
2
3
...