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Accessories to the crime: functions of cells recruited to the tumor microenvironment.
Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types, which presents interesting new targets for anticancer therapy. Expand
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
The studies that brought MPIs into clinical testing are reviewed and the design and outcome of the trials are discussed in light of new information about the cellular source, substrates, and mode of action of MMPs at different stages of tumor progression. Expand
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Examination of the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy suggested enhanced systemic and antitumor immunity in responding patients with a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from responding patients. Expand
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
Blockade of pathways mediating macrophage recruitment, in combination with chemotherapy, significantly decreases primary tumor progression, reduces metastasis, and improves survival by CD8+ T-cell-dependent mechanisms, thus indicating that the immune microenvironment of tumors can be reprogrammed to instead foster antitumor immunity and improve response to cytotoxic therapy. Expand
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals closeExpand
Inflammation and Cancer
Differences between acute and chronic inflammation in the context of cancer, how each state arises, and how each can be manipulated for development of new cancer therapeutics are outlined. Expand
Paradoxical roles of the immune system during cancer development
The paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development is examined and recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis are highlighted. Expand
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the humanExpand
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior. Expand
Understanding the tumor immune microenvironment (TIME) for effective therapy
By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed. Expand