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Bioavailability studies with etodolac in dogs and man.
TLDR
Coadministration of an antacid, magaldrate, or the antiulcer agent, sucralfate, had no effect on the bioavailability of etodolac in dogs, although with the latter, a significant reduction in Cmax was noted.
Sensitive high-performance liquid chromatographic method for the determination of etodolac in serum.
TLDR
A sensitive high-performance liquid chromatographic method for the determination of etodolac in serum was developed and showed the specificity of the method was demonstrated by the lack of response obtained with a variety of control sera, sera spiked with etdolac congeners, and sera obtained from rats treated with a range of other drugs.
A sensitive method for the determination of hydrochlorothiazide in serum by high pressure liquid chromatography.
A high pressure liquid chromatographic method for the determination of hydrochlorothiazide in serum has been elaborated and verified in a blood level study in normal individuals given a single oral
A high pressure liquid chromatographic determination of p-chlorophenoxyisobutyric acid and its comparison to a GLC and an ultra violet spectrophotometric method.
A rapid and reliable method for the determination of clofibric acid in serum using high pressure liquid chromatography has been elaborated and compared to a GLC and UV spectophotometric procedure.
A semi-automated determination of serum triglycerides.
Summary 1. A semi-automated determination of serum triglycerides based on the manual procedure of Laurell has been developed. 2. All evaporation steps are avoided. 3. The oxidation of glycerol to
A method for the analysis of chlorhexidine in serum.
A colorimetric method for the determination of chlorhexidine in serum or plasma has been elaborated; the limit of detection of the method is 25 ng/ml, based on 10 ml of serum or plasma.
An automated method for the analysis of nicotinic acid in serum.
TLDR
An automated colorimetric method for the analysis of nicotinic acid in serum has been elaborated and it is shown that the method is greater than 90% specific for nicotinics acid.
Pharmacokinetics and disposition of the lipid‐lowering drug acifran in normal subjects and in patients with renal failure
TLDR
The results show that acifran is very well absorbed, is rapidly eliminated, is excreted in the urine, and does not undergo any detectable biotransformation in healthy human subjects.
Medrogestone: analysis in serum by high-pressure liquid chromatography.
TLDR
A method for the determination of 6,17-dimethylpregna-4,6-diene-3,20-dione (medrogestone) in serum is described using high-pressure liquid chromatography with UV detection and has a limit of detection of 2 ng/ml.
Colorimetric determination of C-10 hydroxylated metabolites of cyheptamide: application to absorption and enzyme induction studies in the rat.
TLDR
A colorimetric procedure was developed for the quantitative estimation of some C-10 hydroxylated derivatives of cyheptamide and the lactones derived by acid-catalyzed rearrangement and it was demonstrated that in the rat, cy heptamide undergoes limited absorption which can be enhanced by micronization.
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