• Publications
  • Influence
Overview of the therapeutic potential of piplartine (piperlongumine).
TLDR
It is concluded that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials.
In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
TLDR
Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides and it was shown that both organs were reversibly affected by piplartine and piperine treatment, but in a different way.
In vitro and in vivo antitumor effect of 5‐FU combined with piplartine and piperine
TLDR
Piplartine may enhance the therapeutic effectiveness of chemotherapeutic drugs, and moreover, this combination could improve immunocompetence hampered by 5‐FU, according to the findings.
Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells.
TLDR
Analysis of membrane integrity and morphological modifications by flow cytometry in the presence of these two compounds indicated that treated cells undergo necrosis, while 1 and 2 trigger apoptosis, which indicates apoptosis induction.
Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz‐Pifferer)
TLDR
Cf‐PLS has some interesting anticancer activity that could be associated with its immunostimulating properties, and acts as an immunomodulatory agent, raising theproduction of specific antibodies, and increasing the production of OVA‐specific antibodies.
In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species
TLDR
Piperlonguminine did not show any significant in vitro cytotoxic effect at experimental exposure levels, but showed an in vivo antitumor effect, reinforcing the anticancer potential of spice components.
Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
TLDR
To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied.
The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin.
TLDR
The destruction of sea urchin embryos, the inhibition of tumor cell growth and the hemolysis of mouse and human erythrocytes indicate the potential cytotoxicity of kaurenoic acid.
Attenuating effects of melatonin on pilocarpine-induced seizures in rats.
TLDR
Melatonin partially recovered [3H]GABA binding in the hippocampus in the presence of pilocarpine-induced seizures, and intensified pilocarine effects in the striatum of adult rats.
Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells.
TLDR
The present data point to the importance of pristimerin as representative of an emerging class of potential anticancer chemicals, exhibiting an antiproliferative effect by inhibiting DNA synthesis and triggering apoptosis.
...
1
2
3
4
5
...