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Identification of a Novel Hypothalamic Neuropeptide Y Receptor Associated with Feeding Behavior*
TLDR
Cloning by expression of a novel NPY receptor subtype from a rat hypothalamus cDNA library shows that the rat and human Y5 receptors have high affinity for the peptides that elicit feeding and low affinity for nonstimulating peptides, suggesting that it is the NPY feeding receptor sub type. Expand
Molecular Characterization of a Second Mouse Pancreatic Polypeptide Receptor and Its Inactivated Human Homologue*
TLDR
Cloned PP2 suggests that in mouse there are at least two PP receptors, Y4/PP1 and PP2, whereas in humans, PP2 is either functionally inactive or it has acquired a PP-independent function. Expand
Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase.
Although many different types of compounds have been tested for 5-hydroxytryptamine1A (5-HT1A) binding affinity, much remains to be learned about the structural requirements associated with 5-HT1AExpand
Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family
TLDR
Tissue distribution studies in mouse and humans suggest potential roles of this novel receptor in the gastrointestinal tract, heart, prostate, as well as in neural and endocrine signalling. Expand
Cloning and expression of the human galanin receptor GalR2.
TLDR
With the identification of a second galanin receptor subtype, the specific functions of human GalR2 receptor subtypes can now begin to be addressed. Expand
[3H]2-phenylaminoadenosine ([3H]CV 1808) labels a novel adenosine receptor in rat brain.
TLDR
Results indicate that [3H]CV 1808 binding consists of two components in rat brain: a low-affinity site with A1-like characteristics, and a novel high-Affinity site, designated as the A4 receptor, where potassium channel activation appears to be a functional correlate. Expand
I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.
TLDR
The data suggest that NGD 94-1 functions as an antagonist rather than a full or partial agonist at the human D4.2 receptor subtype, and the clinical use of this subtype-specific compound should permit direct evaluation of the role of D4 receptors in psychiatric disorders. Expand
Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.
TLDR
The data suggest that (S)-UH-301 is a 5-HT1A-receptor antagonist without intrinsic activity, and it is likely that it will become a valuable pharmacological tool in future 5- HT research. Expand
High affinity interleukin-6 binding sites in bovine hypothalamus.
TLDR
The present data provide the first reported evidence of high affinity binding sites for [125I]IL- 6 in brain tissue, specifically bovine hypothalamic membranes, and support the proposed involvement of IL-6 in communication between neural and immune systems. Expand
MDL 73005EF: partial agonist at the 5-HT1A receptor negatively linked to adenylate cyclase.
TLDR
It is demonstrated that MDL 73005EF also acts as a highly efficacious partial agonist at the 5HT1A receptor, based on its ability to inhibit forskolin-stimulated adenylate cyclase in rat hippocampal membranes. Expand
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