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Assessment of seizure liability of Org 306039, a 5-HT2c agonist, using hippocampal brain slice and rodent EEG telemetry.
- C. Markgraf, E. Deboer, Jin Zhai, L. Cornelius,, Ying-Ying Zhou, C. Macsweeney
- Journal of pharmacological and toxicological…
- 1 November 2014
In vitro and in vivo models complement each other in the characterization of the seizure potential of CNS-targeted compounds such as the 5-HT2c agonist Org 306039, indicating seizure-genic potential. Expand