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Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic…
We have shown that diabetes-induced reduction in endoneurial blood flow (EBF) and impaired endothelium-dependent vascular relaxation precede slowing of motor nerve conduction velocity (MNCV) and… Expand
Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats.
- C. Oltman, Laura L Richou, E. Davidson, L. Coppey, D. D. Lund, M. Yorek
- Medicine, Biology
- American journal of physiology. Heart and…
- 1 October 2006
We investigated the progression of vascular dysfunction associated with the metabolic syndrome with and without hyperglycemia in lean, Zucker obese, and Zucker diabetic fatty (ZDF) rats. Responses of… Expand
Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats.
- C. Oltman, L. Coppey, J. S. Gellett, E. Davidson, D. D. Lund, M. Yorek
- American journal of physiology. Endocrinology and…
- 1 July 2005
We have examined the progression of vascular and neural deficits in Zucker rats, Zucker diabetic fatty (ZDF) diabetic rats, and age-matched lean ZDF rats from 8 to 40 wk of age. Both the ZDF diabetic… Expand
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice
Male C57BL/6J mice raised on high fat diet (HFD) become prediabetic and develop insulin resistance and sensory neuropathy. The same mice given low doses of streptozotocin are a model of type 2… Expand
Slowing of Motor Nerve Conduction Velocity in Streptozotocin-induced Diabetic Rats is Preceded by Impaired Vasodilation in Arterioles that Overlie the Sciatic Nerve
- L. Coppey, E. Davidson, J. Dunlap, D. D. Lund, M. Yorek
- Chemistry, Medicine
- International journal of experimental diabetes…
Diabetes mellitus produces marked abnormalities in motor nerve conduction, but the mechanism is not clear. In the present study we hypothesized that in the streptozotocin (STZ)-induced diabetic rat… Expand
Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction.
OBJECTIVE Increased oxidative stress and myocyte apoptosis co-exist in the remote non-infarcted myocardium (RM) following a large myocardial infarction. We proposed that these phenomena are causally… Expand
ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy in streptozotocin-induced diabetic rats.
ACE inhibition and/or blocking of the angiotensin II receptor are recognized as first-line treatment for nephropathy and cardiovascular disease in diabetic patients. However, little information is… Expand
Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats.
- E. Davidson, L. Coppey, R. Kardon, M. Yorek
- Investigative ophthalmology & visual science
- 3 March 2014
PURPOSE Peripheral neuropathy has been shown to exist in prediabetic and diabetic patients and animal models. However, the development of peripheral neuropathy in prediabetes and posthyperglycemia is… Expand
Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes.
- Hanna Shevalye, M. Yorek, +4 authors M. Yorek
- Medicine, Psychology
- Journal of neurophysiology
- 1 July 2015
The purpose of this study was to determine the effect of supplementing the diet of a mouse model of type 2 diabetes with menhaden (fish) oil or daily treatment with resolvin D1 on diabetic… Expand
Activation of JNK in the remote myocardium after large myocardial infarction in rats.
- W. Li, A. Zaheer, L. Coppey, H. Óskarsson
- Medicine, Biology
- Biochemical and biophysical research…
- 29 May 1998
A large myocardial infarction (MI) causes a chronic hemodynamic load on the uninjured remote myocardium (RM). This may lead to oxidative stress, activation of stress-induced cell signaling and… Expand