L. Cooper

Publications29
h-index13
Citations795
Highly Influential Citations41
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Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
TLDR
The structures of the two mature haloduracin peptides Halα and Halβ were investigated, indicating that they have similarities as well as some distinct differences compared with other two-component lantibiotics.
Structure-activity relationship studies of the two-component lantibiotic haloduracin.
TLDR
It is established that Halalpha-Ser26 and Halbeta-Ser22 escape dehydration, requiring revision of the Halbeta structure previously proposed, and the Halalpha cystine that is dispensable for bioactivity protects Halalpha from further proteolytic degradation.
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.
TLDR
In vitro processing of semisynthetic substrates unrelated to the prelacticin 481 peptide demonstrated the broad substrate tolerance of LctM and a chemoenzymatic strategy was employed to generate novel thioether linkages by cyclization of peptidic substrates containing the nonproteinogenic cysteine analogs homocysteine and beta-homocysteines.
Nine Post-translational Modifications during the Biosynthesis of Cinnamycin
TLDR
A small protein encoded by cinorf7 is critical for the formation of the cross-link between Lys19 and dehydroalanine 6 as shown by coexpression studies of CinA, CInM, CinX, and Cinorf 7 in E. coli.
The importance of the leader sequence for directing lanthionine formation in lacticin 481.
TLDR
Surprisingly, a conserved Glu located in a ring that appears conserved in many class II lantibiotics, including those not belonging to the lacticin 481 subgroup, is not essential for antimicrobial activity of lactic in 481.
Thiamine deficiency in Cambodian infants with and without beriberi.
TLDR
Thiamine deficiency is endemic among infants and nursing mothers in rural southeastern Cambodia and is often clinically inapparent, and neither heavy metal toxicity nor consumption of thiaminase-containing foods account for thiamines deficiency in this region.
Reversal of the substrate specificity of CMP N-glycosidase to dCMP.
TLDR
The structures of MilB and BcmB are determined and compared to previously determined structures of NDT superfamily members, and comparisons reveal how these enzymes differentiate between ribosyl and deoxyribosyl nucleotides or nucleosides and among different nucleobases.
Chapter 21. In vitro studies of lantibiotic biosynthesis.
The lantibiotics are ribosomally synthesized and posttranslationally modified peptide antibiotics containing the thioether crosslinks lanthionine (Lan) and 3-methyllanthionine (MeLan) and typically…
Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions*
TLDR
The radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme are described, many of which have no precedent in organic or biological chemistry.
Isozymic Characterization of Three Mating Groups of the Tetrahymena pyriformis complex
TLDR
It is concluded that strains identifiable as T. cosmopolitanis are no longer available, and the amicronucleate strains are now placed in the Tetrahymena sp.
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