Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
- Amanda L. McClerren, L. Cooper, C. Quan, P. Thomas, N. Kelleher, W. A. van der Donk
- BiologyProceedings of the National Academy of Sciences
- 14 November 2006
The structures of the two mature haloduracin peptides Halα and Halβ were investigated, indicating that they have similarities as well as some distinct differences compared with other two-component lantibiotics.
Structure-activity relationship studies of the two-component lantibiotic haloduracin.
- L. Cooper, Amanda L. McClerren, Anita Chary, W. A. van der Donk
- BiologyChemistry and Biology
- 20 October 2008
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.
- C. Chatterjee, Gregory C. Patton, L. Cooper, Moushumi Paul, W. A. van der Donk
- Biology, ChemistryChemistry and Biology
- 1 October 2006
Nine Post-translational Modifications during the Biosynthesis of Cinnamycin
- Ayşe Ökesli, L. Cooper, E. Fogle, W. A. van der Donk
- Biology, ChemistryJournal of the American Chemical Society
- 19 July 2011
A small protein encoded by cinorf7 is critical for the formation of the cross-link between Lys19 and dehydroalanine 6 as shown by coexpression studies of CinA, CInM, CinX, and Cinorf 7 in E. coli.
The importance of the leader sequence for directing lanthionine formation in lacticin 481.
- Gregory C. Patton, Moushumi Paul, L. Cooper, C. Chatterjee, W. A. van der Donk
- Biology, ChemistryBiochemistry
- 21 June 2008
Surprisingly, a conserved Glu located in a ring that appears conserved in many class II lantibiotics, including those not belonging to the lacticin 481 subgroup, is not essential for antimicrobial activity of lactic in 481.
Thiamine deficiency in Cambodian infants with and without beriberi.
- D. Coats, Kelsey Shelton-Dodge, M. Topazian
- MedicineJornal de Pediatria
- 1 November 2012
Reversal of the substrate specificity of CMP N-glycosidase to dCMP.
- M. D. Sikowitz, L. Cooper, T. Begley, P. Kaminski, S. Ealick
- Biology, ChemistryBiochemistry
- 11 June 2013
The structures of MilB and BcmB are determined and compared to previously determined structures of NDT superfamily members, and comparisons reveal how these enzymes differentiate between ribosyl and deoxyribosyl nucleotides or nucleosides and among different nucleobases.
Chapter 21. In vitro studies of lantibiotic biosynthesis.
- Bo Li, L. Cooper, W. A. van der Donk
- BiologyMethods in Enzymology
- 2009
Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions*
- Angad P Mehta, Sameh H. Abdelwahed, T. Begley
- Chemistry, BiologyJournal of Biological Chemistry
- 4 December 2014
The radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme are described, many of which have no precedent in organic or biological chemistry.
Isozymic Characterization of Three Mating Groups of the Tetrahymena pyriformis complex
- D. L. Nanney, L. Cooper, E. Simon, G. S. Whitt
- Biology
- 1 November 1980
It is concluded that strains identifiable as T. cosmopolitanis are no longer available, and the amicronucleate strains are now placed in the Tetrahymena sp.
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