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Complete Relative Stereochemistry of Maitotoxin
By addressing the relative stereochemistry of the four acyclic portions via organic synthesis, the complete relative stereochemistry of maitotoxin (MTX) has been established as 1B. The relative…
The Stereochemical Assignment and Conformational Analysis of the V/W- Ring Juncture of Maitotoxin
The Stereochemical Assignment and Conformational Analysis of the V/W-Ring Juncture of Maitotoxin
The unambiguous stereochemical assignment of the V/W-ring juncture of maitotoxin, as shown in Figure 1, was accomplished using a two-step approach: (1) the synthesis of two diastereomeric models…
Erythrocyte arginase, pyrimidine 5'-nucleotidase (P5N), and deoxypyrimidine 5'-nucleotidase (dP5N) as indices of lead exposure.
HBPLC assay of rbc UMPase activity is a sensitive and rapid assay that appears to meet criteria for a reliable clinical laboratory index of blood lead concentrations, equivalent to rbc protoporphyrin.
Erythrocyte membrane microviscosity and phospholipid composition in lead workers.
- L. Cook, S. Stohs, C. Angle, T. Hickman, R. C. Maxell
- Biology, ChemistryBritish journal of industrial medicine
- 1 December 1987
Alterations in the microviscosity of the lipid regions of the hydrophobic core of the erythrocyte membrane bilayer and in the phospholipid composition of the membrane may be defects which contribute to the clinical and biochemical instability of the red blood cell on exposure to lead.
Assay of human erythrocyte pyrimidine and deoxypyrimidine 5'-nucleotidase by isocratic reversed-phase high-performance liquid chromatography.
Prediction of blood lead by HPLC assay of erythrocyte pyrimidine 5'-nucleotidase.
Wider utilization of P5N, measured as UMPase, is proposed as a biologic correlate of blood lead.
Erythrocyte pyrimidine 5'-nucleotidase and deoxynucleotidase isozymes: metallosensitivity and kinetics.
The metallosensitivities of the P5N isozymes using UMP, dUMP, dCMP and dTMP as the substrates were defined and contrary to previously reported data, there was enzyme activity with all five substrates.
881 ERYTHROCYTE PYRIMIDINE 5′ NUCLEOTIDASE ISOENZYMES IN CONGENITAL DEFICIENCY AND IN LEAD EXPOSURE
The maximal affinity of the enzyme for the deoxypyrimidines suggests a role in the clearance of DNA as well as RNA during red cell maturation and in vitro sensitivity to Pb2+ and Cu2+ is more evident in normal rbc than PND.