• Publications
  • Influence
The Host Shapes the Gut Microbiota via Fecal MicroRNA.
The host gut microbiota varies across species and individuals but is relatively stable over time within an individual. How the host selectively shapes the microbiota is largely unclear. Here, we showExpand
  • 290
  • 28
  • PDF
An Ecological Network of Polysaccharide Utilization among Human Intestinal Symbionts
BACKGROUND The human intestine is colonized with trillions of microorganisms important to health and disease. There has been an intensive effort to catalog the species and genetic content of thisExpand
  • 220
  • 13
  • PDF
The evolution of cooperation within the gut microbiota
Cooperative phenotypes are considered central to the functioning of microbial communities in many contexts, including communication via quorum sensing, biofilm formation, antibiotic resistance, andExpand
  • 264
  • 12
  • PDF
Extensive surface diversity of a commensal microorganism by multiple DNA inversions
The dynamic interactions between a host and its intestinal microflora that lead to commensalism are unclear. Bacteria that colonize the intestinal tract do so despite the development of a specificExpand
  • 260
  • 8
A General O-Glycosylation System Important to the Physiology of a Major Human Intestinal Symbiont
The Bacteroides are a numerically dominant genus of the human intestinal microbiota. These organisms harbor a rare bacterial pathway for incorporation of exogenous fucose into capsularExpand
  • 126
  • 8
Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements
BackgroundType VI secretion systems (T6SSs) are contact-dependent antagonistic systems employed by Gram negative bacteria to intoxicate other bacteria or eukaryotic cells. T6SSs were recentlyExpand
  • 85
  • 7
Human Symbionts Use a Host-Like Pathway for Surface Fucosylation
The mammalian intestine harbors a beneficial microbiota numbering approximately 1012 organisms per gram of colonic content. The host tolerates this tremendous bacterial load while maintaining theExpand
  • 203
  • 6
Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species
Significance Mechanisms of competition are not well-studied in the mammalian gut microbiota, especially among abundant species of this ecosystem. Theoretical models predict that antagonisticExpand
  • 111
  • 6
  • PDF
A Defined O-Antigen Polysaccharide Mutant of Francisella tularensis Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity
ABSTRACT Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol,Expand
  • 67
  • 6
Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota
A common human gut bacterium, Bacteroides fragilis, produces a sphingolipid ligand for the conserved host receptor CD1d and can modulate natural killer T cell activity.
  • 155
  • 5
  • PDF