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The advantages and disadvantages of being polyploid
  • L. Comai
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 November 2005
Polyploids — organisms that have multiple sets of chromosomes — are common in certain plant and animal taxa, and can be surprisingly stable. The evidence that has emerged from genome analyses alsoExpand
Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis.
Chemical mutagenesis has been the workhorse of traditional genetics, but it has not been possible to determine underlying rates or distributions of mutations from phenotypic screens. However,Expand
Genomewide Nonadditive Gene Regulation in Arabidopsis Allotetraploids
Polyploidy has occurred throughout the evolutionary history of all eukaryotes and is extremely common in plants. Reunification of the evolutionarily divergent genomes in allopolyploids createsExpand
Phenotypic Instability and Rapid Gene Silencing in Newly Formed Arabidopsis Allotetraploids
Allopolyploid hybridization serves as a major pathway for plant evolution, but in its early stages it is associated with phenotypic and genomic instabilities that are poorly understood. We haveExpand
Targeting induced local lesions IN genomes (TILLING) for plant functional genomics.
One of the most important breakthroughs in the history of genetics was the discovery that mutations can be induced ([Muller, 1930][1]; [Stadler, 1932][2]). The high frequency with which ionizingExpand
Centromeric Localization and Adaptive Evolution of an Arabidopsis Histone H3 Variant Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010425.
Centromeric H3-like histones, which replace histone H3 in the centromeric chromatin of animals and fungi, have not been reported in plants. We identified a histone H3 variant from ArabidopsisExpand
Targeted screening for induced mutations
With the accumulation of large-scale sequence data, emphasis in genomics has shifted from determining gene structure to testing gene function, and this relies on reverse genetic methodology. Here weExpand
Remodeling of DNA Methylation and Phenotypic and Transcriptional Changes in Synthetic Arabidopsis Allotetraploids1
The joining of different genomes in allotetraploids played a major role in plant evolution, but the molecular implications of this event are poorly understood. In synthetic allotetraploids ofExpand
Discovery of chemically induced mutations in rice by TILLING
BackgroundRice is both a food source for a majority of the world's population and an important model system. Available functional genomics resources include targeted insertion mutagenesis andExpand
Understanding mechanisms of novel gene expression in polyploids.
Polyploidy has long been recognized as a prominent force shaping the evolution of eukaryotes, especially flowering plants. New phenotypes often arise with polyploid formation and can contribute toExpand