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Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy
Mammalian Atg9 (mAtg9) is a multispanning membrane protein that resides in a novel compartment. mAtg9 interacts dynamically with phagophores and forming autophagosomes. It is proposed that mAtg9Expand
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Human VPS34 is required for internal vesicle formation within multivesicular endosomes
After internalization from the plasma membrane, activated EGF receptors (EGFRs) are delivered to multivesicular bodies (MVBs). Within MVBs, EGFRs are removed from the perimeter membrane to internalExpand
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Constitutive sharing of recycling synaptic vesicles between presynaptic boutons
The synaptic vesicle cycle is vital for sustained neurotransmitter release. It has been assumed that functional synaptic vesicles are replenished autonomously at individual presynaptic terminals.Expand
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Regulated and Polarized PtdIns(3,4,5)P3 Accumulation Is Essential for Apical Membrane Morphogenesis in Photoreceptor Epithelial Cells
BACKGROUND In a specialized epithelial cell such as the Drosophila photoreceptor, a conserved set of proteins is essential for the establishment of polarity, its maintenance, or both--in Drosophila,Expand
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Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes
Rab GTPases are regulators of intracellular membrane traffic. We report a possible function of Rab27a, a protein implicated in several diseases, including Griscelli syndrome, choroideremia, and theExpand
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HIV‐1 Trafficking to the Dendritic Cell–T‐Cell Infectious Synapse Uses a Pathway of Tetraspanin Sorting to the Immunological Synapse
Dendritic cells (DCs) are essential components of the early events of HIV infection. Here, we characterized the trafficking pathways that HIV‐1 follows during its capture by DCs and its subsequentExpand
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Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis
At the end of cell division, cytokinesis splits the cytoplasm of nascent daughter cells and partitions segregated sister genomes. To coordinate cell division with chromosome segregation, the mitoticExpand
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Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination.
How melanoma acquire a metastatic phenotype is a key issue. One possible mechanism is that metastasis is driven by microenvironment-induced switching between noninvasive and invasive states. However,Expand
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Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
Autophagosome formation requires sequential translocation of autophagy-specific proteins to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest autophagy-specificExpand
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A Human Genome-wide Screen for Regulators of Clathrin-coated Vesicle Formation Reveals an Unexpected Role for the V-ATPase
Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi-step siRNA-based screening strategy to identify regulators of the first step in clathrin-mediatedExpand
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