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Complex spliceosomal organization ancestral to extant eukaryotes.
In higher eukaryotes, introns are spliced out of protein-coding mRNAs by the spliceosome, a massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By comparing theExpand
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Genomics and the Irreducible Nature of Eukaryote Cells
Large-scale comparative genomics in harness with proteomics has substantiated fundamental features of eukaryote cellular evolution. The evolutionary trajectory of modern eukaryotes is distinct fromExpand
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Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.
Thromboxane A, (TxAJ causes contraction of vascular smooth muscle and aggregation of platelets; paradoxically, it also induces formation of the vasodilator and antiaggregant prostacyclin by humanExpand
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Mutational Dynamics of Aroid Chloroplast Genomes
A characteristic feature of eukaryote and prokaryote genomes is the co-occurrence of nucleotide substitution and insertion/deletion (indel) mutations. Although similar observations have also beenExpand
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A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.
The polyketide toxin dothistromin is very similar in structure to the aflatoxin precursor, versicolorin B. Dothistromin is made by a pine needle pathogen, Dothistroma septosporum, both in culture andExpand
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Computational Identification of Four Spliceosomal snRNAs from the Deep-Branching Eukaryote Giardia intestinalis
RNAs processing other RNAs is very general in eukaryotes, but is not clear to what extent it is ancestral to eukaryotes. Here we focus on pre-mRNA splicing, one of the most important RNA-processingExpand
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Additions and Corrections to Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.
Thromboxane A2 (TxA2) causes contraction of vascular smooth muscle and aggregation of platelets; paradoxically, it also induces formation of the vasodilator and antiaggregant prostacyclin by humanExpand
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Two New Fern Chloroplasts and Decelerated Evolution Linked to the Long Generation Time in Tree Ferns
We report the chloroplast genomes of a tree fern (Dicksonia squarrosa) and a “fern ally” (Tmesipteris elongata), and show that the phylogeny of early land plants is basically as expected, and theExpand
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Efficacy of four conjugal lactococcal phage resistance plasmids against phage in commercial Lactococcus lactis subsp. cremoris cheese starter strains
The efficacy of four lactococcal phage resistance plasmids (pNP40, pMU1311, pDI60 and pKP100) against phage was assessed after their conjugal transfer to four commercial Lactococcus lactis subsp.Expand
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Use of RNA Secondary Structure for Studying the Evolution of RNase P and RNase MRP
Abstract. Secondary structure is evaluated for determining evolutionary relationships between catalytic RNA molecules that are so distantly related they are scarcely alignable. The ribonucleoproteinsExpand
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