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Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles.
TLDR
Premenopausal women with no lifetime history of major depression who entered the perimenopause were twice as likely to develop significant depressive symptoms as women who remained premenopausal, after adjustment for age at study enrollment and history of negative life events. Expand
Relapse of Major Depression During Pregnancy in Women Who Maintain or Discontinue Antidepressant Treatment
TLDR
Pregnancy is not “protective” with respect to risk of relapse of major depression, and women with histories of depression who are euthymic in the context of ongoing antidepressant therapy should be aware of the association of depressive relapse during pregnancy with antidepressant discontinuation. Expand
Prevalence of body dysmorphic disorder in a community sample of women.
TLDR
The author's estimate of the point prevalence of body dysmorphic disorder is consistent with data from a community-based sample of Italian women and suggests a prevalence similar to that of other serious psychiatric disorders in women. Expand
Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently
TLDR
Cognitive improvement with ET is associated with hot flushes, but not with sleep, suggesting that ET has a direct central nervous system effect, rather than an indirect effect mediated through improvement of sleep. Expand
Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation.
TLDR
Treatment planning for pregnant women with bipolar disorder should consider not only the relative risks of fetal exposure to mood stabilizers but also the high risk of recurrence and morbidity associated with stopping maintenance mood stabilizer treatment. Expand
Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial.
TLDR
Transdermal estradiol replacement is an effective treatment of depression for perimenopausal women and sustained antidepressant benefit of treatment after the 4-week washout period, although somatic complaints increased in frequency and intensity. Expand
A reevaluation of risk of in utero exposure to lithium.
TLDR
More recent epidemiologic data indicate that the teratogenic risk of first-trimester lithium exposure is lower than previously suggested, and the clinical management of women with bipolar disorder who have childbearing potential should be modified with this revised risk estimate. Expand
Premenstrual Daily Fluoxetine for Premenstrual Dysphoric Disorder: A Placebo‐Controlled, Clinical Trial Using Computerized Diaries
TLDR
Premenstrual daily dosing with fluoxetine effectively treats mood, physical, and social functioning symptoms associated with premenstrual dysphoric disorder. Expand
Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy.
TLDR
Lithium completely equilibrates across the placenta, and higher lithium concentrations at delivery are associated with more perinatal complications, and lithium concentrations can be reduced by brief suspension of therapy proximate to delivery. Expand
Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants.
TLDR
Potentially important gender differences in certain illness characteristics were found in certain patients with bipolar illness; however, in contrast to other reports, this study did not find higher rates of lifetime depressive episodes or rapid cycling in women. Expand
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