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Direct imaging of lateral movements of AMPA receptors inside synapses
- C. Tardin, L. Cognet, C. Bats, B. Lounis, D. Choquet
- Biology, Physics
- The EMBO journal
- 15 September 2003
The data show that rapid exchange of receptors between a synaptic and extra‐synaptic localization occurs through regulation of receptor diffusion inside synapses, and that this process is driven by inhibition of inhibitory transmission to favor excitatory synaptic activity. Expand
Endocytic Trafficking and Recycling Maintain a Pool of Mobile Surface AMPA Receptors Required for Synaptic Potentiation
- E. M. Petrini, Jiuyi Lu, L. Cognet, B. Lounis, M. Ehlers, D. Choquet
- Medicine, Biology
- 16 July 2009
It is demonstrated that the presence of both EZs and AMPAR recycling maintain a large pool of mobile AMPARs at synapses, and it is found that synaptic potentiation is accompanied by an accumulation and immobilization of AM PARs atsynapses resulting from both their exocytosis and stabilization at the PSD. Expand
NMDA receptor surface mobility depends on NR2A-2B subunits
- L. Groc, M. Heine, +4 authors D. Choquet
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 5 December 2006
The developmental change in the synaptic surface content of NR2A and NR2B subunits was correlated with a developmental changein the time spent by the subunits within synapses, suggesting that the switch in synaptic NMDAR subtypes depends on the regulation of the receptor surface trafficking. Expand
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Different lateral mobilities for AMPARs and NMDARs are found: changes in neuronal activity modified AMPAR but not NMDar mobility, whereas protein kinase C activation modified both. Expand
Stepwise Quenching of Exciton Fluorescence in Carbon Nanotubes by Single-Molecule Reactions
- L. Cognet, D. Tsyboulski, John-David R. Rocha, Condell D. Doyle, J. Tour, R. Weisman
- Chemistry, Physics
- 8 June 2007
Single-molecule chemical reactions with individual single-walled carbon nanotubes were observed through near-infrared photoluminescence microscopy, providing highly efficient sensing of local chemical and physical perturbations. Expand
Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density.
It is shown here that the unprecedented large statistics obtained by uPAINT on single cells reveal local diffusion properties of specific proteins, either in distinct membrane compartments of adherent cells or in neuronal synapses. Expand
Single-molecule imaging of the H-ras membrane-anchor reveals domains in the cytoplasmic leaflet of the cell membrane.
To investigate the presence of cytoplasmic leaflet domains, the H-Ras membrane-targeting sequence was fused to the C-terminus of the enhanced yellow fluorescent protein and results show that the diffusion of 30-40% of the molecules is constrained in domains with a typical size of 200 nm. Expand
Autofluorescent proteins in single-molecule research: applications to live cell imaging microscopy.
- G. Harms, L. Cognet, P. H. Lommerse, G. Blab, T. Schmidt
- Biology, Medicine
- Biophysical journal
- 1 May 2001
The yellow-fluorescent protein mutant eYFP is superior compared to all the fluorescent proteins for single-molecule studies in vivo and is found to dynamically track the entity to which it is anchored when bound to membranes of live cells. Expand
Observation of intrinsic size effects in the optical response of individual gold nanoparticles.
The photothermal heterodyne imaging method is used to study for the first time the absorption spectra of individual gold nanoparticles with diameters down to 5 nm, and disturbances in the peak energies and homogeneous widths of the single-particle resonances are revealed. Expand
Photothermal heterodyne imaging of individual nonfluorescent nanoclusters and nanocrystals.
- S. Berciaud, L. Cognet, G. Blab, B. Lounis
- Materials Science, Medicine
- Physical review letters
- 13 December 2004
A new, highly sensitive, and simple heterodyne optical method for imaging individual nonfluorescent nanoclusters and nanocrystals that allows for the unprecedented detection of individual small absorptive objects such as metallic clusters or nonluminescent semiconductor nanocrystal. Expand