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Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation.
P-450 forms PB-1, 2c, and PB-4 are the major catalysts of cyclophosphamide activation in rat hepatic tissue and that the modulation of microsomal cycloph phosphamide activation with development and in response to drug exposure largely reflects alterations in the levels of these three hepatic P-450 enzymes.
Adsorption of plasma from tumor-bearing hosts over protein A--containing nonviable Staphylococcus aureus Cowan I: possible mechanism of antitumor reactions.
Adsorption of autologous plasma over nonviable Staphylococcus aureus Cowan I (SAC) followed by reinfusion of the plasma causes regression of (a) chemically induced rat mammary adenocarcinomas (MA),
Studies on the mechanism of corticosteroid-induced lymphocytolysis.
When cells of the thymus or corticosteroid-sensitive mouse lymphosarcoma P1798S are treated in vitro with 0.27 µm cortisol in tissue culture medium with 10% serum or 0.5% human albumin, nuclear
Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide.
The findings establish that the cytotoxic effects of thiotepa are oxygen dependent and may involve, at least in part, metabolic processes catalyzed by cytochrome P-450 enzymes.
3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.
Experiments suggested that TID binds to the substrate-binding site of P-450 PB-4, and microsomes isolated from uninduced or beta-naphthoflavone-induced livers are shown to be resistant to extensive proteolytic digestion.
Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs.
Structural features which are important for inhibition of human liver FPGS are identified and may therefore prove useful for the design of new compounds having potential as chemotherapeutic agents.
Flow Cytometric Detection of Procoagulant Properties of Plasma from Patients with Clinically Confirmed Vaccine-Induced Immune Thrombotic Thrombocytopenia
An alternative flow cytometric assay to diagnose VITT was described, hypothesized that priming of platelets with a PAR1 agonist at a level sufficient to release PF4, but insufficient to generate a significant procoagulant response in donor platelets, would provide a platform in which pro coagulants response would be dependent on presence of FcγRIIa dependent procoAGulant antibodies in patient plasma, without requirement for additional PF4.
Studies on the mechanism of action of the chemotherapeutic drug bleomycin on cell lines derived from haemangioma and keloid
Results from this study show that bleomycin induces apoptosis of haemangioma, venous malformation and keloid derived cells in a dose dependent manner, and it is reported for the first time that bleomecin induces a caspase-3 mediated apoptotic cell death in keloids derived cells.