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Defining the Neural Mechanisms of Probabilistic Reversal Learning Using Event-Related Functional Magnetic Resonance Imaging
Event-related functional magnetic resonance imaging was used to measure blood oxygenation level-dependent responses in 13 young healthy human volunteers during performance of a probabilisticExpand
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Decision-making processes following damage to the prefrontal cortex.
Recent work has suggested an association between the orbitofrontal cortex in humans and practical decision making. The aim of this study was to investigate the profile of cognitive deficits, withExpand
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Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies
There is a longstanding association between substance-use disorders (SUDs) and the psychological construct of impulsivity. In the first section of this review, personality and neurocognitive dataExpand
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Cognitive enhancing effects of modafinil in healthy volunteers
Abstract Rationale. Modafinil, a novel wake-promoting agent, has been shown to have a similar clinical profile to that of conventional stimulants such as methylphenidate. We were therefore interestedExpand
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Reflection Impulsivity in Current and Former Substance Users
BACKGROUND Chronic drug use is associated with increased impulsivity, risky decision making, and impaired behavioral control, but the underlying mechanisms of this neurocognitive profile remainExpand
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Sustained attention deficit in bipolar disorder.
BACKGROUND Recovery in bipolar disorder is central to its definition but is rarely complete. Previous work has suggested that neuropsychological impairment persists during the euthymic state but hasExpand
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Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
The ventromedial prefrontal cortex (vmPFC) and insular cortex are implicated in distributed neural circuitry that supports emotional decision-making. Previous studies of patients with vmPFC lesionsExpand
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Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans
Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical rolesExpand
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Gambling Near-Misses Enhance Motivation to Gamble and Recruit Win-Related Brain Circuitry
Summary “Near-miss” events, where unsuccessful outcomes are proximal to the jackpot, increase gambling propensity and may be associated with the addictiveness of gambling, but little is known aboutExpand
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Serotonin selectively influences moral judgment and behavior through effects on harm aversion
Aversive emotional reactions to real or imagined social harms infuse moral judgment and motivate prosocial behavior. Here, we show that the neurotransmitter serotonin directly alters both moralExpand
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