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Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.
- C. Weston, E. L. Shepherd, +12 authors D. Adams
- Biology, Medicine
- The Journal of clinical investigation
- 2 February 2015
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte accumulation in the form… Expand
Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults
- L. Claridge, B. Eksteen, A. Smith, T. Shah, A. Holt
- BMJ : British Medical Journal
- 2 December 2010
A total of 4 g of paracetamol repeated daily may be hepatotoxic in malnourished adults with low body weight
Sound production in species of Rhynchaenus (= Orchestes) (Coleoptera: Curculionidae)
- L. Claridge
- 24 April 2009
A 22 year old man presents with a resolving episode of mild jaundice after an influenza-like illness. He reports a previous episode after an appendicectomy, which also resolved spontaneously, but he… Expand
Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake.
- S. Karim, E. Liaskou, +6 authors P. Lalor
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 15 December 2014
Insulin resistance is common in patients with chronic liver disease (CLD). Serum levels of soluble vascular adhesion protein-1 (VAP-1) are also increased in these patients. The amine oxidase activity… Expand
Low Free Triiodothyronine Is Associated with Advanced Fibrosis in Patients at High Risk for Nonalcoholic Steatohepatitis
BackgroundThyroid hormone is critical for tissue–organ development, growth, differentiation, and metabolism. In murine models of advanced nonalcoholic steatohepatitis (NASH), the administration of T3… Expand
Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.
INTRODUCTION Liver fibrosis develops when hepatic stellate cells (HSC) are activated into collagen-producing myofibroblasts. In non-alcoholic steatohepatitis (NASH), the adipokine leptin is… Expand