• Publications
  • Influence
Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics.
TLDR
In this prospective randomized trial, clozAPine, olanzapine, and haloperidol were associated with an increase of plasma glucose level, and clozapine and olanZapine were associatedWith an increase in cholesterol levels.
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder.
TLDR
Patients with a history of suboptimal response to conventional treatments may show cognitive benefits from newer antipsychotic drugs, and there may be differences between atypical antipsychotics drugs in their patterns of cognitive effects.
Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology.
TLDR
The authors present consensus guidelines that operationalize criteria for determining and reporting treatment resistance, adequate treatment, and treatment response, providing a benchmark for research and clinical translation in schizophrenia.
Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second‐generation antipsychotic
  • L. Citrome
  • Psychology, Medicine
    International journal of clinical practice
  • 1 February 2011
TLDR
The efficacy and safety of lurasidone for the treatment of schizophrenia is described and the drug is shown to be safe and effective.
The Use of Long-Acting Injectable Antipsychotics in Schizophrenia: Evaluating the Evidence.
TLDR
The evidence review demonstrated that LAIs are superior to placebo for acute and maintenance treatment of schizophrenia and, in general, appear to be similar to one another in terms of schizophrenia relapse prevention.
Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder.
TLDR
Clozapine shows greater efficacy than olanZapine and olanzapine great efficacy than haloperidol in reducing aggressive behavior and this antiaggressive effect appears to be separate from the antipsychotic and sedative action of these medications.
Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder.
TLDR
The overall pattern of results suggests that clozapine and olanzapine have similar general antipsychotic efficacy and that risperidone may be somewhat less effective.
Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability
  • L. Citrome
  • Medicine, Psychology
    Expert opinion on drug metabolism & toxicology
  • 15 January 2013
TLDR
The chemistry, pharmacodynamic profile, pharmacokinetics, and clinical profile of cariprazine, an atypical antipsychotic in clinical development for the treatment of schizophrenia and bipolar mania/mixed episodes, are described.
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