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Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs.
Compounds that bind in the minor groove of DNA have found use in the experimental treatment of cancer and certain infectious diseases. Furthermore, agents which target and can recognize discreteExpand
Epoxide opening versus silica condensation during sol-gel hybrid biomaterial synthesis.
Hybrid organic-inorganic solids represent an important class of engineering materials, usually prepared by sol-gel processes by cross-reaction between organic and inorganic precursors. The choice ofExpand
Epitope affinity for MHC class I determines helper requirement for CTL priming
We show here that priming and memory generation of antigen-specific CD8+ cytotoxic T lymphocytes (CTL) does not require help if the immunogen binds major histocompatibility complex (MHC) class IExpand
VA-086 methacrylate gelatine photopolymerizable hydrogels: A parametric study for highly biocompatible 3D cell embedding.
The ability to replicate in vitro the native extracellular matrix (ECM) features and to control the three-dimensional (3D) cell organization plays a fundamental role in obtaining functionalExpand
Targeting bacterial membranes: NMR spectroscopy characterization of substrate recognition and binding requirements of D-arabinose-5-phosphate isomerase.
Lipopolysaccharide (LPS) is an essential component of the outer membrane of gram-negative bacteria and consists of three elements: lipid A, the core oligosaccharide, and the O-antigen. The inner-coreExpand
Kdo: a critical monosaccharide for bacteria viability.
Covering: 2000 to 2010 Kdo belongs to the 3-deoxysugar ‘family’ and is a critical monosaccharidic component of lipopolysaccharides (LPSs) in Gram-negative bacteria. The incorporation of Kdo intoExpand
Synthesis of azasugars by Grignard reaction on glycosylamines
Abstract Pyrrolidines 5a-b, and piperidines 10a,b and 15, were synthesised by Grignard reaction on a glycosylamine, easily obtained from the parent sugar and a primary amine, followed by cyclizationExpand
Stereoselective synthesis of the isosteric phosphono analogues of N-acetyl-alpha-D-glucosamine 1-phosphate and N-acetyl-alpha-D-mannosamine 1-phosphate
The isosteric phosphono analogues of N-acetyl-α-d-glucosamine 1-phosphate and N-acetyl-α-d-mannosamine 1-phosphate (1 and 2) are stereoselectively synthesized starting fromExpand
Trans fatty acid content of a selection of foods in Argentina
Abstract Several studies have reported an association between consumption of trans fatty acids and risk of cardiovascular disease (CVD). These fatty acids enter the human diet most commonly asExpand
Carbonate hydroxyapatite functionalization: a comparative study towards (bio)molecules fixation
Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improveExpand