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Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial.
TLDR
Adding oxaliplatin to fluorouracil-based preoperative chemoradiotherapy significantly increases toxicity without affecting primary tumor response. Expand
Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials.
TLDR
The easy-to-use nomograms can predict LR, DM, and OS over a 5-year period after surgery and may be used as decision support tools in future trials by using the three defined risk groups to select patients for postoperative chemotherapy and close follow-up. Expand
Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data.
TLDR
Overall, adjuvant fluorouracil-based chemotherapy did not improve overall survival, disease-free survival, or distant recurrences, but aduvant chemotherapy might benefit patients with a tumour 10-15 cm from the anal verge in terms of disease- free survival and distant recurrence. Expand
Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients.
TLDR
A ypCR after neoadjuvant therapy identified a favorable group of patients, even in this large series of 566 patients collected in 61 centers, to verify whether yp CR predicts a favorable outcome in a largeseries of patients. Expand
No benefit of adjuvant Fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): Long term results of a randomized trial (I-CNR-RT).
TLDR
In patients with LARC treated with NACT-RT, the addition of ACT did not improve 5year OS and DFS and had no impact on the distant metastasis rate. Expand
Long-term safety of orbital radiotherapy for Graves' ophthalmopathy.
TLDR
In conclusion, OR is a safe treatment, not associated with an increased frequency of cataract, provided a high voltage apparatus is used, and hypertension, especially if associated with diabetes, may represent a relative contraindication, as it may cause retinopathy. Expand
A multi-institutional phase II study on second-line Fotemustine chemotherapy in recurrent glioblastoma
TLDR
Fotemustine was safe and effective as second-line chemotherapy in recurrent glioblastoma, with few manageable haematological toxicities. Expand
Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients.
TLDR
DPD activity in PBMNC is unrelated to 5-FU/5-FDHU disposition and patients with severe toxicity display marked pharmacokinetic alterations while a reduction of DPD activity may not occur. Expand
Accuracy of endoanal ultrasound in the follow-up assessment for squamous cell carcinoma of the anal canal treated with radiochemotherapy
TLDR
Endoanal ultrasound is a safe and effective method for evaluating and following anal cancer before and after treatment and could give a clear idea concerning the evolution of the anal tumors treated with radiochemotherapy. Expand
The volume effect in radiation-related late small bowel complications: results of a clinical study of the EORTC Radiotherapy Cooperative Group in patients treated for rectal carcinoma.
TLDR
It is demonstrated that there is a volume-effect in radiation-induced diarrhea at a dose of 50 Gy in 25 fractions in pelvic postoperative radiotherapy, and no volume- effect for small bowel obstruction was detected at this dose-level in pelvic Postoperative Radotherapy. Expand
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