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Therapeutic antibody targeting of individual Notch receptors
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. LigandExpand
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TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
Transforming growth factor‐β (TGF‐β), a secreted factor present at high levels in bone, inhibits osteoblast differentiation in culture; yet, the mechanism of this inhibition remains unclear. WeExpand
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Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function*
  • L. Choy, R. Derynck
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 14 March 2003
Transforming growth factor (TGF)-β is a potent inhibitor of adipocyte differentiation. To identify which adipocyte transcription factors might be targeted by TGF-β, we overexpressed key adipogenicExpand
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Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation
TGF-β inhibits adipocyte differentiation, yet is expressed by adipocytes. The function of TGF-β in adipogenesis, and its mechanism of action, is unknown. To address the role of TGF-β signaling inExpand
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A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor
TRANSFORMING growth factor-β (TGF-β) is the prototype for a family of extracellular polypeptides that affect cell proliferation and differentiation, and tissue morphogenesis1. TGF-β signalling isExpand
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The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila.
Tiggrin is a novel extracellular matrix ligand for the Drosophila PS2 integrins. We have used flanking P elements to generate a precise deletion of tiggrin. Most flies lacking tiggrin die as larvaeExpand
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Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
Mesenchymal cells can differentiate into osteoblasts, adipocytes, myoblasts, or chondroblasts. Whether mesenchymal cells that have initiated differentiation along one lineage can transdifferentiateExpand
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TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch
During the course of breast cancer progression, normally dormant tumour‐promoting effects of transforming growth factor β (TGFβ), including migration, invasion, and metastasis are unmasked. In anExpand
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Differential effects of targeting Notch receptors in a mouse model of liver cancer
Primary liver cancer encompasses both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The Notch signaling pathway, known to be important for the proper development of liver architecture,Expand
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Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.
Transgenic mice were produced containing the adipocyte-specific regulatory region from the adipocyte P2 (aP2) gene linked to the simian virus 40 transforming genes. Most of the transgenic miceExpand
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