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DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression
Modifications at the N-terminal tails of nucleosomal histones are required for efficient transcription in vivo. We analyzed how H3 histone methylation and demethylation control expression ofExpand
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Increased BDNF promoter methylation in the Wernicke area of suicide subjects.
CONTEXT Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology of suicidal behavior and BDNF levels are decreased in the brain and plasma of suicide subjects. So far,Expand
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Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
We have determined the complete nucleotide sequence of the histidine operons of Escherichia coli and of Salmonella typhimurium. This structural information enabled us to investigate the expressionExpand
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Insect-based diet, a promising nutritional source, modulates gut microbiota composition and SCFAs production in laying hens
Insects could be potential nutritional sources both for humans and animals. Among these, Hermetia illucens, with good amount of chitin and proteins, represents a suitable diet replacement for layingExpand
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A Novel Member of the BTB/POZ Family, PATZ, Associates with the RNF4 RING Finger Protein and Acts as a Transcriptional Repressor*
We have identified a novel human gene encoding a 59-kDa POZ-AT hook-zinc finger protein (PATZ) that interacts with RNF4, a mediator of androgen receptor activity, and acts as a transcriptionalExpand
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Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors.
The insulin-like growth factors (IGFs), IGF-I and IGF-II, occur in plasma and tissue fluids complexed to specific binding proteins. Although the role of the binding proteins is not completelyExpand
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The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis
We recently isolated the r-PTPeta gene, which encodes a receptor-type tyrosine phosphatase protein that suppresses the neoplastic phenotype of retrovirally transformed rat thyroid cells. The humanExpand
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TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters
We have recently reported that a novel MBD2 interactor (MBDin) has the capacity to reactivate transcription from MBD2-repressed methylated promoters even in the absence of demethylation events. HereExpand
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The rat tyrosine phosphatase η increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
The expression of the receptor protein tyrosine phosphatase r-PTPη is drastically reduced in rat and human malignant thyroid cells, whereas its restoration reverts the neoplastic phenotype ofExpand
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Galectin‐1 and galectin‐3 expression in human bladder transitional‐cell carcinomas
Galectin‐1 and galectin‐3 are galactoside‐binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectinsExpand
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