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Antiviral activities of extracts and selected pure constituents of Ocimum basilicum
1. Ocimum basilicum (OB), also known as sweet basil, is a well known medicinal herb in traditional Chinese medicine preparations. In the present study, extracts and purified components of OB wereExpand
Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species.
TLDR
It is concluded that saikosaponin c exhibits anti-HBV activity and saikOSaponin d possesses potent cytotoxicity against human hepatocellular carcinoma cells. Expand
Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.
TLDR
Two new sesquiterpene coumarins were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation and showed greater potency against influenza A virus than amantadine and exhibited the best potency against HepG2, Hep3B, and MCF-7 cancer cell lines. Expand
Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells.
TLDR
The present study concludes that the anti-hepatoma activity of apigenin is as effective as 5-FU and its apoptotic mechanism might be mediated through the p53-dependent pathway and the induction of p21 expression. Expand
ANTIVIRAL EFFECTS OF SAIKOSAPONINS ON HUMAN CORONAVIRUS 229E IN VITRO
TLDR
The present results indicate that saikosaponin B2 has potent anticoronaviral activity and that its mode of action possibly involves interference in the early stage of viral replication, such as absorption and penetration of the virus. Expand
Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells.
TLDR
It was demonstrated that the resveratrol effectively inhibited cell growth and induced programmed cell death in Hepatoma cells on a molecular basis and implied that resver atrol might also be a new potent chemopreventive drug candidate for liver cancer. Expand
Antiviral activity of Plantago major extracts and related compounds in vitro.
TLDR
Pure compounds of P. major, which possess antiviral activities are mainly derived from the phenolic compounds, especially caffeic acid, which was found to be at multiplication stages against HSV-2 and ADV-3, suggesting the potential use of this compound for treatment of the infection by these two viruses. Expand
In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids.
TLDR
The mode of action of quercetin against HSV-1 and ADV-3 was found to be at the early stage of multiplication and with SI values greater than 20, suggesting the potential use of this compound for treatment of the infection caused by these two viruses. Expand
Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion.
TLDR
A novel mechanism by which HDAC inhibitors suppress tumor invasion and provides a new strategy for cancer therapy is revealed. Expand
Increase of Bax/ Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line.
TLDR
It is suggested that luteolin might exhibit anti-HCC activity as efficient as 5-FU by the mechanism of not only cell cycle arrest but also apoptosis. Expand
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