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- Publications
- Influence
Structure of Taylor cone-jets : limit of low flow rates
- L. Cherney
- Physics
- 10 January 1999
In this paper the structure of the Taylor meniscus and emitted
jet is studied by perturbation methods in the limit of low flow rates. An asymptotic system
of governing equations is derived from the… Expand
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
- R. Sankaranarayanan, M. Cherney, L. Cherney, C. Garen, Fatemeh Moradian, M. James
- Chemistry, Medicine
- Journal of molecular biology
- 25 January 2008
Mycobacterium tuberculosis ornithine carbamoyltransferase (Mtb OTC) catalyzes the sixth step in arginine biosynthesis; it produces citrulline from carbamoyl phosphate (CP) and ornithine (ORN). Here,… Expand
The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.
- M. Cherney, L. Cherney, C. Garen, M. James
- Chemistry, Medicine
- Journal of molecular biology
- 4 November 2011
Phosphoribosyl pyrophosphate (PRPP) synthetase catalyzes the transfer of the pyrophosphate group from ATP to ribose-5-phosphate (R5P) yielding PRPP and AMP. PRPP is an essential metabolite that plays… Expand
Universal drag tag for direct quantitative analysis of multiple microRNAs.
- David W. Wegman, L. Cherney, G. Yousef, S. Krylov
- Chemistry, Medicine
- Analytical chemistry
- 19 June 2013
Using microRNA (miRNA) as molecular markers of diseases requires a method for accurate measurement of multiple miRNAs in biological samples. Direct quantitative analysis of multiple miRNAs (DQAMmiR)… Expand
Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.
- L. Cherney, M. Cherney, C. Garen, George J. Lu, M. James
- Biology, Medicine
- Acta crystallographica. Section D, Biological…
- 1 September 2008
The Mycobacterium tuberculosis (Mtb) gene product encoded by open reading frame Rv1657 is an arginine repressor (ArgR). All genes involved in the L-arginine (hereafter arginine) biosynthetic pathway… Expand
Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.
- L. Cherney, M. Cherney, C. Garen, George J. Lu, M. James
- Biology, Materials Science
- Journal of molecular biology
- 31 December 2008
The arginine repressor (ArgR) from Mycobacterium tuberculosis (Mtb) is a gene product encoded by the open reading frame Rv1657. It regulates the L-arginine concentration in cells by interacting with… Expand
Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).
- L. Cherney, M. Cherney, C. Garen, Chunying Niu, Fatemeh Moradian, M. James
- Chemistry, Medicine
- Journal of molecular biology
- 5 September 2006
The enzyme N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductive dephosphorylation of… Expand
Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis.
- S. J. Witholt, R. Sankaranarayanan, C. Garen, M. Cherney, L. Cherney, M. James
- Biology, Medicine
- Acta crystallographica. Section F, Structural…
- 1 June 2008
The gene product of open reading frame Rv3117 from Mycobacterium tuberculosis (Mtb) strain H37Rv is annotated as encoding a probable rhodanese-like thiosulfate sulfurtransferase (MtbCysA3). MtbCysA3… Expand
High throughput crystallography of TB drug targets.
- A. C. Murillo, H. Y. Li, +21 authors J. Sacchettini
- Biology, Medicine
- Infectious disorders drug targets
- 31 May 2007
Tuberculosis (TB) infects one-third of the world population. Despite 50 years of available drug treatments, TB continues to increase at a significant rate. The failure to control TB stems in part… Expand
Extracting kinetics from affinity capillary electrophoresis (ACE) data: a new blade for the old tool.
- M. Kanoatov, L. Cherney, S. Krylov
- Chemistry, Medicine
- Analytical chemistry
- 9 January 2014
We describe a mathematical approach that enables extraction of kinetic rate constants from thousands of studies conducted over the past two decades with affinity capillary electrophoresis (ACE).… Expand
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