Nitric Oxide in Traumatic Brain Injury
- L. Cherian, R. Hlatky, C. Robertson
- BiologyBrain Pathology
- 1 April 2004
Pre‐injury treatment with 7‐nitroindazole is effective in improving neurological outcome in some models of traumatic brain injury (TBI), and administration of L‐arginine at this early time improves CBF, and outcome in many models.
Axon Initial Segment–Associated Microglia
- Kelli L Baalman, M. A. Marin, M. Rasband
- Biology, PsychologyJournal of Neuroscience
- 4 February 2015
It is reported that in the cortex, but not other brain regions, a subset of microglia extend a single process that specifically associates and overlaps with the axon initial segment (AIS), the site where action potentials are generated.
Lateral cortical impact injury in rats: pathologic effects of varying cortical compression and impact velocity.
- J. Goodman, L. Cherian, R. Bryan, C. Robertson
- BiologyJournal of Neurotrauma
- 1 October 1994
Cortical deformation and impact velocity are critical parameters in producing cortical contusion and must be considered when comparing results using this model.
Lateral cortical impact injury in rats: cerebrovascular effects of varying depth of cortical deformation and impact velocity.
- L. Cherian, C. Robertson, C. Contant, R. Bryan
- BiologyJournal of Neurotrauma
- 1 October 1994
Intracranial pressure, blood pressure, cerebral perfusion pressure, and cortical perfusion of the contralateral parietal cortex were measured after cortical impact injury in 36 rats to compare changes in these physiologic parameters to a group of 11 rats who received a sham impact.
L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats.
- L. Cherian, C. Robertson
- Biology, MedicineJournal of Neurotrauma
- 2003
The theory that L-arginine administration improves post-traumatic cerebral blood flow by increasing NO production supports the theory that free radical production after trauma may also contribute to the reduction in CBF by inactivating NO.
Effect of glucose administration on contusion volume after moderate cortical impact injury in rats.
- L. Cherian, J. Goodman, C. Robertson
- BiologyJournal of Neurotrauma
- 1 December 1998
The hypothesis that glucose administration adversely affects experimental traumatic brain injury in those circumstances where the trauma is complicated by primary cerebral ischemia, such as around cortical contusions, is supported.
Cerebral hemodynamic effects of phenylephrine and L-arginine after cortical impact injury.
- L. Cherian, G. Chacko, J. Goodman, C. Robertson
- Medicine, BiologyCritical Care Medicine
- 1998
Phenylephrine increased cerebral blood flow (CBF) by increasing CPP and L-arginine increased CBF without changing CPP, and the improvement in CBF was accompanied by a decrease in neurologic injury.
Neuroprotection with Erythropoietin Administration Following Controlled Cortical Impact Injury in Rats
- L. Cherian, J. Goodman, C. Robertson
- BiologyJournal of Pharmacology and Experimental…
- 1 August 2007
Data demonstrate the neuroprotective effects of Epo in traumatic injury, and the effects are optimal when Epo is given with in 6 h of injury.
Brain nitric oxide changes after controlled cortical impact injury in rats.
- L. Cherian, J. Goodman, C. Robertson
- Medicine, BiologyJournal of Neurophysiology
- 1 April 2000
Preinjury treatment with L-nitro-arginine methyl ester blunted the injury-induced increase in NO and resulted in more severe immediate intracranial hypertension and more severe systemic hypotension at one hour after injury.
Hyperglycemia increases brain injury caused by secondary ischemia after cortical impact injury in rats.
- L. Cherian, J. Goodman, C. Robertson
- Medicine, BiologyCritical Care Medicine
- 1 August 1997
Hyperglycemia increases brain damage when traumatic brain injury is complicated by secondary ischemia.
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