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CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.
TLDR
In SB immune-mediated diseases, there is repartitioning of CCR9(+) lymphocytes between SB and blood and an altered pattern of TECK expression in SB Crohn's, and the TECK/CCR9 ligand/receptor pair may play an important role in the pathogenesis of SBCrohn's disease. Expand
Increased TRPV1 gene expression in esophageal mucosa of patients with non‐erosive and erosive reflux disease
TLDR
Transient receptor potential channel vanilloid subfamily member‐1 (TRPV1) may play a role in esophageal perception and was examined in the esophagesia of non‐erosive reflux disease and erosive esophagitis patients and correlated to esophAGEal acid exposure. Expand
Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease
TLDR
Transplanting autologous patient‐derived enteric neuronal stem/progenitor cells (ENSCs) is an innovative approach to replacing missing enteric neurons in patients with Hirschsprung disease, but whether postnatal aganglionic bowel is permissive for transplanted ENSCs and whether EN SCs from HSCR patients can be successfully isolated, cultured, and transplanted in vivo remains unknown. Expand
Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease
TLDR
A novel, minimally invasive endoscopic method of cell delivery is proposed for transplantation of enteric neural stem cells (ENSC) as a potential therapy for enteric neuropathies, including Hirschsprung disease. Expand
Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation
TLDR
Females with slow transit constipation exhibit progesterone receptor overexpression in colon muscle that impair their contractility, and whether P4 affects the SERT‐5‐HT pathway is examined. Expand
Platelet‐activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non‐erosive reflux disease patients and controls
TLDR
Assessment of inflammatory mediators in mucosal biopsies from EE and NERD patients and compared them with controls confirmed the presence of inflammatory response in the mucosa of EE patients, leading to damage of mucosal integrity. Expand