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The complete genome of an individual by massively parallel DNA sequencing
The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. However, theExpand
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NF-AT components define a family of transcription factors targeted in T-cell activation
THE NF-AT transcription complex1 is required for the expression of a group of proteins that collectively coordinate the immune response2–4 . Here we purify two proteins encoded by separate genes thatExpand
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Cooperative Intersection Management: A Survey
  • L. Chen, Cristofer Englund
  • Computer Science, Engineering
  • IEEE Transactions on Intelligent Transportation…
  • 1 February 2016
Intersection management is one of the most challenging problems within the transport system. Expand
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A transcriptional hierarchy involved in mammalian cell-type specification
ALTHOUGH transcriptional hierachies have been extensively studied in invertebrates, their involvement in mammalian cell-type specification is poorly understood1,2. Here we report a hepatocyteExpand
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Validation of reference genes for RT-qPCR studies of gene expression in banana fruit under different experimental conditions
Reverse transcription quantitative real-time PCR (RT-qPCR) is a sensitive technique for quantifying gene expression, but its success depends on the stability of the reference gene(s) used for dataExpand
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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
The AMP-activated protein kinase (AMPK) is characterized by its ability to bind to AMP, which enables it to adjust enzymatic activity by sensing the cellular energy status and maintain the balanceExpand
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Structure of a Pancreatic ATP-Sensitive Potassium Channel
ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have beenExpand
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Identification of aluminum-responsive microRNAs in Medicago truncatula by genome-wide high-throughput sequencing
MicroRNAs (miRNAs) play important roles in response of plants to biotic and abiotic stresses. Aluminum (Al) toxicity is a major factor limiting plant growth in acidic soils. However, there has beenExpand
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AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
  • L. Chen, J. Wang, +5 authors J. Wu
  • Chemistry, Medicine
  • Nature Structural &Molecular Biology
  • 1 July 2012
The energy sensor AMP-activated protein kinase (AMPK) is a heterotrimeric complex that is allosterically activated by AMP binding to the γ subunit. Cocrystal structures of the mammalian AMPK coreExpand
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This study examined the association between particulate matter ≤ 10 µm in aerodynamic size (PM 10), carbon monoxide (CO), and ozone (O 3), and birth weight in Washoe County, NV, from 1991 throughExpand
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