L. Chen

Publications214
h-index30
Citations3,992
Highly Influential Citations145
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Structural basis of YAP recognition by TEAD4 in the hippo pathway.
The Hippo signaling pathway controls cell growth, proliferation, and apoptosis by regulating the expression of target genes that execute these processes. Acting downstream from this pathway is the… Expand
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Modular structure of sodium-coupled bicarbonate transporters
SUMMARY Mammalian genomes contain 10 SLC4 genes that, between them, encode three Cl–HCO3 exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter, and what is reported… Expand
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Structure of the Dom34–Hbs1 complex and implications for no-go decay
No-go decay (NGD) targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. The crystal structure of a Schizosaccharomyces… Expand
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Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance
Multidrug resistance (MDR) is one of the main obstacles in tumor chemotherapy. A promising approach to solving this problem is to utilize a nontoxic and potent modulator able to reverse MDR, which in… Expand
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The hippo pathway in biological control and cancer development
The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis.… Expand
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A pilot study of umbilical cord‐derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis
  • L. Wang, J. Li, +13 authors F. Wang
  • Medicine
  • Journal of gastroenterology and hepatology
  • 15 July 2013
BACKGROUND AND AIM Ursodeoxycholic acid (UDCA) treatment is an effective medical therapy for patients with primary biliary cirrhosis (PBC); however, 40% of PBC patients show an incomplete response to… Expand
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The Physiology of Bicarbonate Transporters in Mammalian Reproduction1
ABSTRACT HCO3– plays critically important roles during virtually the entire process of reproduction in mammals, including spermatogenesis, sperm capacitation, fertilization, and development of early… Expand
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Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway
The control of organ size growth is one of the most fundamental aspects of life. In the past two decades, a highly conserved Hippo signaling pathway has been identified as a key molecular mechanism… Expand
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Degradation of polycyclic aromatic hydrocarbons by microbial consortia enriched from three soils using two different culture media.
A consortium composed of many different bacterial species is required to efficiently degrade polycyclic aromatic hydrocarbons (PAH) in oil-contaminated soil. We obtained six PAH-degrading microbial… Expand
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The Role of Transposable Elements in the Origin and Evolution of MicroRNAs in Human
MicroRNAs (miRNAs) are crucial regulators of gene expression at the post-transcriptional level in eukaryotes via targeting gene 3'-untranslated regions. Transposable elements (TEs) are considered as… Expand
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